苯磺酸氨氯地平联合倍他乐克治疗顽固性高血压的临床疗效观察

Clinical observation of amlodipine besylate combined with Betaloc in the treatment of refractory hypertension

目的探究苯磺酸氨氯地平联合酒石酸美托洛尔(商品名:倍他乐克)治疗顽固性高血压的临床疗效。方法98例顽固性高血压患者,依据整群随机法分为对照组与观察组,各49例。对照组采用苯磺酸氨氯地平治疗,观察组采用苯磺酸氨氯地平联合倍他乐克治疗。对比两组治疗前后血压及心率水平。结果治疗后,观察组收缩压、舒张压分别为(128.6±10.6)、(84.8±5.6)mm Hg(1 mm Hg=0.133 kPa),均低于对照组的(133.4±8.3)、(90.4±6.2)mm Hg,差异均有统计学意义(P<0.05)。治疗后,观察组心率水平为(72.6±2.8)次/min,低于对照组的(76.5±2.4)次/min,差异有统计学意义(P<0.05)。结论苯磺酸氨氯地平联合倍他乐克治疗顽固性高血压疗效显著,可有效改善患者血压及心率水平,值得在临床中推广应用。

Objective To investigate the clinical efficacy of amlodipine besylate combined with metoprolol tartrate(trade name:Betaloc)in the treatment of refractory hypertension.Methods A total of 98 patients with refractory hypertension were divided into the control group and the observation group according to the cluster random method,with 49 cases in each group.The control group was treated with amlodipine besylate,and the observation group was treated with amlodipine besylate combined with Betaloc.The blood pressure and heart rate before and after treatment were compared between the two groups.Results After treatment,the systolic blood pressure and diastolic blood pressure in the observation group were(128.6±10.6)and(84.8±5.6)mm Hg(1 mm Hg=0.133 kPa),which were lower than(133.4±8.3)and(90.4±6.2)mm Hg in the control group,and the difference was statistically significant(P<0.05).After treatment,the heart rate of the observation group was(72.6±2.8)beats/min,which was lower than(76.5±2.4)beats/min of the control group,and the difference was statistically significant(P<0.05).Conclusion Amlodipine besylate combined with Betaloc has significant efficacy in the treatment of refractory hypertension,which can effectively improve the blood pressure and heart rate of patients,and is worthy of clinical promotion and application.