抗肿瘤药物常见的溶媒错误及合理用药效果分析

Analysis of common solvent errors of anti-tumor drugs and the effect of rational drug use

目的分析在抗肿瘤药物溶媒中的常见错误,并对此做好相关总结,以减少临床不合理用药现象。方法回顾性分析本院所应用的500份抗肿瘤处方,总结和分析处方中常见的溶媒错误、溶媒量不足等问题,并就此提出合理用药建议。结果500份抗肿瘤处方中,共出现不适宜处方25份,占比5.00%。25份不适宜处方中超剂量处方3份,占比12.00%;超说明用药4份,占比16.00%;溶媒量不足7份,占比28.00%;溶媒错误11份,溶媒错误占比44.00%。溶媒错误处方占比高于其他不适宜处方。结论合理的溶媒选择是抗肿瘤药物在临床安全应用中的重点,不仅需要在溶媒的选择、使用剂量、使用浓度、流程等各个环节工作中加强把控,更需要严格按照说明书执行,以此降低临床中使用抗肿瘤药物时不良反应的发生风险,与此同时,还应对整个溶媒工作流程进行层层把关,以从根本上降低抗肿瘤药物在临床应用中的不合理现象,保证药物使用的安全和合理性。

Objective To analyze common errors in anti-tumor drug solvent,and make relevant summaries to reduce the phenomenon of irrational drug use in clinical practice.Methods The 500 anti-tumor prescriptions used in our hospital were analyzed retrospectively,and the common solvent errors,insufficient solvent and other problems in the prescription were summarized and analyzed,and rational drug use suggestions were put forward.Results Among the 500 anti-tumor prescriptions,there were 25 inappropriate prescriptions,accounting for 5.00%.Among 25 inappropriate prescriptions,there were 3 over-dose prescriptions,accounting for 12.00%;4 prescriptions of off-label medication,accounting for 16.00%;7 prescriptions of insufficient amount of solvent,accounting for 28.00%;11 prescriptions of solvent errors,accounting for 44.00%.The percentage of prescriptions with solvent errors was higher than other inappropriate prescriptions,and the difference was statistically significant(P<0.05).Conclusion Reasonable solvent selection is the key point in the clinical safety application of antitumor drugs.It not only needs to strengthen the control in the selection of solvent,dosage,concentration and process,but also needs to be implemented in strict accordance with the instructions,so as to reduce the risk of adverse reactions when using anti-tumor drugs in clinic.At the same time,the whole solvent work process should be checked at all levels,in order to fundamentally reduce the unreasonable phenomenon of anti-tumor drugs in clinical application and ensure the safety and rationality of drug use.