TMSB10表达水平与胃癌患者淋巴结转移及早期进展的相关性

Correlation of TMSB10 expression level with lymph node metastasis and early progression in gastric cancer patients

目的探讨胸腺素β10(TMSB10)在胃癌组织中的表达水平及其与患者淋巴结转移及早期进展的相关性。方法纳入于我院行胃癌根治术的患者120例,采用免疫组织化学法检测胃癌组织中TMSB10蛋白表达水平,根据术后病理结果是否存在淋巴结转移分为淋巴结转移组(LN组,n=89)和非淋巴结转移组(非LN组,n=31),对比2组患者临床资料,采用Logistic回归分析影响胃癌患者淋巴结转移的危险因素。根据TMSB10蛋白表达中位数将患者分为TMSB10低表达组(60例)和TMSB10高表达组(60例),分析不同TMSB10蛋白表达水平患者术后12个月疾病进展风险。结果120例患者中共有89例出现淋巴结转移,对比2组临床资料显示,LN组患者年龄、肿瘤浸润深度、组织学分型、是否合并溃疡、肿瘤直径及TMSB10蛋白表达水平与非LN组比较差异有统计学意义(P<0.05);多因素Logistic回归分析显示,肿瘤浸润至浆膜层(OR=3.607)、组织学分型为未分化型(OR=1.098)、合并溃疡(OR=3.824)及TMSB10高表达(OR=1.143)是导致胃癌患者出现淋巴结转移的独立危险因素(P<0.05);限制性立方条图显示,TMSB10蛋白表达水平与胃癌患者淋巴结转移风险呈显著线性关系(χ^(2)=1.641,P>0.05)。以TMSB10蛋白表达中位数为界值进行生存分析,结果显示,TMSB10高表达组患者术后早期进展风险明显高于TMSB10低表达组(Log-rankχ^(2)=7.102,P=0.008)。结论TMSB10在胃癌组织中高表达会增加患者淋巴结转移的风险,且与患者术后早期进展风险高度相关。

Objective To investigate the expression level of thymosin beta 10(TMSB10)in gastric cancer tissues and its correlation with lymph node metastasis and early progression of patients.Methods A total of 120 patients underwent radical gastrectomy admitted to our hospital were enrolled.The TMSB10 protein expression in gastric cancer tissue was detected by immunohistochemistry.These patients were divided into the lymph node metastasis group(the LN group,n=89)and the non-lymph node metastasis group(the non-LN group,n=89)according to the postoperative pathological results of lymph node metastasis.The clinical data of the patients in the two groups were compared,and the risk factors affecting lymph node metastasis in gastric cancer patients were analyzed by Logistic regression.According to the median expression of TMSB10 protein,the patients were divided into the TMSB10 low expression group(60 cases)and the TMSB10 high expression group(60 cases),the risk of disease progression 12 months after surgery in patients with different TMSB10 protein expression levels was analyzed.Results A total of 89 cases of the 120 patients had lymph node metastasis.There were statistically significant differences in the age,depth of tumor invasion,histological type,combined with ulcer or not,tumor diameter and TMSB10 protein expression level between the LN group and the non-LN group after compared the clinical data of the two groups(P<0.05);multivariate Logistic regression analysis showed that the tumor infiltrated into the serosal layer(OR=3.607),histological type classified as the undifferentiated type(OR=1.098),combined with ulcer(OR=3.824),and high expression of TMSB10(OR=1.143)were the independent risk factors leading to lymph node metastasis in gastric cancer patients(P<0.05);the restricted cubic spline showed that the TMSB10 protein expression level had a significant linear relationship with the risk of lymph node metastasis in gastric cancer patients(χ^(2)=1.641,P>0.05).The survival analysis was performed with the median expression of TMSB10 protein as the cutoff value,which showed that the early postoperative progression risk of patients in the TMSB10 high expression group was significantly higher than that in the TMSB10 low expression group(Log-rankχ^(2)=7.102,P=0.008).Conclusion The high expression of TMSB10 in gastric cancer tissue can increase the risk of lymph node metastasis of patients,and it is highly correlated with the risk of early postoperative progression.