银杏二萜内酯葡胺注射液联合丁苯酞软胶囊治疗急性脑梗死的临床疗效观察

Clinical effect of Ginkgo diterpenoid lactone glucosamine injection combined with butylphthalide soft capsule in the treatment of acute cerebral infarction

目的评价银杏二萜内酯葡胺注射液与丁苯酞软胶囊联合用于急性脑梗死临床治疗的效果。方法以我院2018年3月至2019年3月的急性脑梗死患者为研究对象,共98例,按治疗方案分为对照组、研究组,每组各49例。对照组患者采用常规治疗+丁苯酞软胶囊治疗方案;研究组在对照组的治疗基础上联合银杏二萜内酯葡胺注射液治疗。比较两组的治疗效果及安全性。结果治疗后,两组患者NIHSS评分较本组治疗前均降低(P<0.05),同时研究组患者NIHSS评分低于对照组(P<0.05);与治疗前相比,治疗后两组的血浆黏度、纤维蛋白原、血小板聚集率以及C反应蛋白、白介素-8均明显降低(P<0.05);同时研究组上述指标低于对照组(P<0.05);对照组、研究组治疗期间不良反应发生率分别为18.37%和20.41%,远期复发率分别为8.16%和2.04%,差异均无统计学意义(P>0.05)。结论银杏二萜内酯葡胺注射液联合丁苯酞软胶囊可有效改善急性脑梗死患者的神经功能与血流动力学,起到抗炎作用,且用药安全性较高、远期复发率较低。

Objective To observe and evaluate the clinical effect of Ginkgo diterpenoid lactone glucosamine injection combined with butylphthalide soft capsule in the treatment of acute cerebral infarction.Methods The clinical data of 98 patients with acute cerebral infarction from March 2018 to March 2019 were selected,and they were divided into control group and study group according to different treatment methods,with 100 in each.Patients in the control group were treated with conventional treatment+butylphthalide soft capsule.On the basis of treatment for the control group,the study group was treated with Ginkgo diterpenoid lactone glucosamine injection.The therapeutic effects and safety were compared between the two groups.Results After treatment,NIHSS score of the two groups was lower than that before treatment(P<0.05),and NIHSS score of the study group was lower than that of the control group(P<0.05);after treatment,compared with before treatment,plasma viscosity,fibrinogen,platelet aggregation rate,C-reactive protein and interleukin-8 of the two groups were lower(P<0.05).Compared with the control group,the above indexes were lower in the study group(P<0.05).The incidence of adverse reactions of the control group and the study group were 18.37%and 20.41%,and the long-term recurrence rate was 8.16%and 2.04%,the difference being not statistically significant(P>0.05).Conclusion Ginkgo diterpenoid lactone glucosamine injection combined with butylphthalide soft capsule can effectively improve the neurological function and hemodynamics of patients with acute cerebral infarction,playing an anti-inflammatory role,and the drug safety is higher and the long-term recurrence rate is lower.