凝血指标与老年脑出血患者病灶体积变化的相关性研究

Correlation between coagulation index and lesion volume change in senile patients with intracerebral hemorrhage

目的:探讨凝血指标与老年脑出血患者病灶体积变化的相关性。方法:选取2016年2月至2020年8月在南通市第三人民医院就诊的老年脑出血患者125例,根据是否发生血肿扩大将其分为控制组和血肿扩大组。检测并对比两组患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血清纤维蛋白原(Fib)、纤维蛋白原降解产物(FDP)及D-二聚体(D-D)的水平、凝血因子Ⅱ、Ⅶ、Ⅷ、Ⅹ的活性。结果:血肿扩大组患者的TT显著长于控制组患者,其血清Fib的水平显著低于控制组患者,其血清FDP、D-D的水平、凝血因子Ⅱ的活性均显著高于控制组患者,差异有统计学意义(P<0.05)。两组患者的PT、APTT、凝血因子Ⅶ、Ⅷ、Ⅹ的活性相比,差异无统计学意义(P>0.05)。结论:老年脑出血患者病灶体积的变化情况与其凝血指标密切相关。

Objective:To investigate the correlation between coagulation index and lesion volume change in elderly patients with intracerebral hemorrhage.Methods:A total of 125 elderly patients with intracerebral hemorrhage treated in the Third People’s Hospital of Nantong city from February 2016 to August 2020 were selected and divided into control group and hematoma enlargement group according to whether hematoma enlargement occurred.The prothrombin time(PT),activated partial thrombin time(APTT),thrombin time(TT),serum fibrinogen(Fib),fibrinogen degradation product(FDP)and D-dimer(DD),and the activities of coagulation factorsⅱ,ⅶ,ⅷ,ⅹin 2 groups were detected and compared.Results:TT in hematoma enlargement group was significantly longer than that in control group,the level of serum Fib was significantly lower than that in control group,the levels of serum FDP and D-D and the activity of coagulation factorⅱwere significantly higher than that in control group,the differences were statistically significant(P<0.05).There were no significant differences in PT,APTT,ⅶ,ⅷ,ⅹactivities between 2 groups(P>0.05).Conclusion:The change of lesion volume in senile patients with intracerebral hemorrhage is closely related to its coagulation index.