米诺膦酸原料药中基因毒性杂质的分析

Analysis of Genotoxic Impurity in Minodronic Acid API

根据米诺膦酸原料药合成工艺路线,全面分析米诺膦酸工艺过程中使用或产生的基因毒性杂质。通过检索遗传毒性数据库和计算机模拟(定量)构效关系((Q)SAR),评估其毒性。

To fully analyze genotoxic impurities used and produced in process for synthesis of minodronic acid.To assess genotoxic impurities’toxicity hazard through retrieving genotoxicity databases and computational simulation using(Q)SAR methodologies.