ChE、cTnI和FIB水平对急性Ⅱ型呼吸衰竭患者预后的影响

Effect of the changes of ChE, cTnI and FIB levels on the prognosis of patients with acute type Ⅱ respiratory failure

目的观察胆碱酯酶(ChE)、心肌肌钙蛋白Ⅰ(cTnI)和纤维蛋白原(FIB)水平对急性重度Ⅱ型呼吸衰竭患者预后的影响。方法根据患者预后转归情况,将80例急性重度Ⅱ型呼吸衰竭患者分为死亡组33例和生存组47例。比较两组ChE、cTnI和FIB水平,绘制ROC曲线评估其对Ⅱ型呼吸衰竭预后的预测价值。结果死亡组ChE水平低于生存组,cTnI和FIB水平高于生存组(P<0.05)。ROC曲线结果显示,ChE、cTnI和FIB的曲下面积均高于0.7(P<0.05),其最佳截断值分别为0.336 kU/L、0.675μg/L和3.345 g/L。结论ChE、cTnI和FIB3在Ⅱ型呼吸衰竭患者血清中水平的变化能预测急性重度Ⅱ型呼吸衰竭患者的预后结局。

Aim To observe the effect of the changes of cholinesterase(ChE),cardiac troponin I(cTnI)and fibrinogen(FIB)levels on the prognosis of patients with acute severe typeⅡrespiratory failure.Methods According to the prognosis of patients,80 patients with acute severe typeⅡrespiratory failure were divided into death group(n=33)and survival group(n=47).The expression levels of ChE,cTnI and FIB were compared between the two groups.The predictive value of those indicators on the prognosis of typeⅡrespiratory failure was evaluated by drawing ROC curve.Results Univariate analysis showed that ChE expression level in the death group was lower than that in the survival group,and cTnI and FIB expression levels in the death group were higher than that in the survival group(P<0.05).ROC curve results showed that the area under the curve of ChE,cTnI and FIB were all higher than 0.7(P<0.05),and the optimal cut-off values were 0.336 kU/L,0.675μg/L and 3.345 g/L.Conclusion The changes of ChE,cTnI and FIB3 expression levels in serum of patients with typeⅡrespiratory failure can predict the prognosis of patients with acute and severe typeⅡrespiratory failure.