SENP3在疾病发生发展中作用的研究进展

Research progress on the role of SENP3 in the pathogenesis and development of diseases

小泛素样修饰蛋白(SUMO)特异性蛋白酶(SENP)能介导SUMO前体加工和去SUMO化修饰,是细胞内SUMO稳态维持的核心调控因子。SENP3是SENP家族成员之一,分布于核仁并优先催化靶蛋白的去SUMO2/3修饰;通过与靶蛋白结合并去SUMO化靶蛋白调节多种胞内蛋白功能。一旦SENP3的表达异常,便会引发一系列细胞异常活动,最终导致疾病的发生发展。本文对SENP3在疾病中的功能研究进展做一综述。

Small ubiquitin-related modifier(SUMO)-specific protease(SENP)family,which can both process small ubiquitin-like modifier(SUMO)precursor maturation and catalyze the SUMO deSUMOylation from target proteins,act as a core factor for sumoylation homeostasis.As one of the SENP family members,SENP3 distributes in nucleolus and preferably deSUMOylate SUMO2/3.SENP3 can alter the interaction with target proteins and following desumoylate them to regulate the function of a variety of cellular proteins.Once the SENP3 expression level varied,the above-mentioned cellular activities will be abnormal,further leading to the occurrence and development of diseases.This review focuses on the recent advances of SENP3’s function in diseases.