DNA甲基化在结直肠癌诊断中的研究进展

Research progress of DNA methylation in the diagnosis of early colorectal cancer

结直肠癌是消化系统常见的肿瘤,恶性程度高,多数患者在出现症状时已经处于疾病晚期。尽管随着影像学水平的进步以及结肠镜检查的普及,传统检查方法的检出率正在不断提高,但是对于早期、无症状的结肠癌诊断仍然不尽如人意。因此,进一步研究结直肠癌的发生、发展机制,从中获得结直肠癌的诊疗新思路显得尤为重要。近年来,随着人们对表观遗传学研究的不断深入,DNA甲基化在结直肠癌的发生过程中起到的作用逐渐为人所关注。本文旨在对DNA甲基化在结直肠癌诊疗中的研究进展进行综述。

Colorectal cancer is a common tumor of the digestive system with a high degree of malignancy.Most patients are in the advanced stages of the disease when they develop symptoms.Although the detection rate of traditional screening methods is improving with advances in imaging and the popularity of colonoscopy,the diagnosis of early,asymptomatic colon cancer is still unsatisfactory.Therefore,it is particularly important to further study the occurrence and development mechanism of colorectal cancer and obtain new ideas for the diagnosis and treatment.?In recent years,with the deepening of epigenetics research,the role of DNA methylation in the pathogenesis of colorectal cancer has gradually attracted attention.This paper will review the research progress of DNA methylation in colorectal cancer′s diagnosis and treatment.