细胞自噬与非小细胞肺癌关系的研究进展

Advances on the Relationship Between Autophagy and Non-small Cell Lung Cancer

细胞自噬是细胞重要的基本代谢过程之一,经常作为非小细胞肺癌的治疗靶点。细胞自噬一方面可以通过维持细胞内基因组的稳定、清除促癌因子、促进细胞程序性死亡、参与免疫反应和支持干细胞维持等多种途径抑制癌细胞的产生,另一方面又可以为癌细胞提供营养物质以支持其生长和迁移并使其产生对放化疗的抗性。因此,厘清自噬与非小细胞肺癌发生发展之间的具体联系,不仅可以更加有针对性地制定治疗策略,也可以为开发新的治疗策略提供思路。全文结合最新的研究成果,对细胞自噬和非小细胞肺癌的关系作一综述。

Autophagy is one of the important basic metabolic processes of cells,which can be used as a therapeutic target for non-small cell lung cancer(NSCLC).Autophagy can inhibit the production of cancer cells by maintaining the stability of intracellular genome,removing cancer promoting factors,promoting programmed cell death,participating in immune response and supporting stem cell maintenance.On the other hand,it can provide nutrients for cancer cells to support their growth and migration and make them resistant to radiotherapy and chemotherapy.Therefore,clarifying the specific relationship between autophagy and the occurrence and development of NSCLC is conducive to improve the current targeted therapy,and to develop new treatment strategies.This article reviews the relationship between autophagy and NSCLC.