Recent Advances of Covalent Organic Frameworks for Chiral Separation

Covalent organic frameworks(COFs), orderly assembled from the building blocks via covalent bonds, are a novel type of porous materials with rich functional sites and permanent porosity. At present, most of COFs are achiral networks, nevertheless, chiral COFs(CCOFs) have become a research hotspot in recent years, due to their unique chiral sites and microenvironment. As one of the most important applications of CCOFs, chiral separation has attracted huge attention for the convenient, rapid and efficient feature. In this review, recent progresses of covalent organic frameworks for chiral separation are covered. And we also present the challenges and outlooks of CCOFs in the future for this field.