低补体荨麻疹性血管炎与系统性红斑狼疮的相关性

The Correlation Between Hypocomplementemic Urticarial Vasculitis and Systemic Lupus Erythematosus

低补体荨麻疹性血管炎(HUV)是一种罕见的自身免疫性疾病,主要表现为荨麻疹性血管炎(UV)和低补体血症。近年来,多项研究报道HUV与系统性红斑狼疮(SLE)之间具有密切的相关性,许多患者两病同时或先后出现。HUV与SLE共同存在可加快疾病进展,导致不良预后。但目前临床上HUV与SLE的区分与共病常常容易被忽视。因此,本文就HUV与SLE在流行病学、临床表现、组织病理学、血清学(补体与自身抗体等)及遗传与变异方面的潜在关联进行阐述,以期提高对两者相关性的认识,为两者的诊断鉴别、早期预防等提供参考。

Hypocomplementemic urticarial vasculitis(HUV)is an uncommon autoimmune disease characterized by urticarial vasculitis(UV)and hypocomplementemia.In recent years,there have been many reports on correlations between HUV and systemic lupus erythematosus(SLE),many patients suffer from two diseases at the same time or successively.The co-existence of HUV and SLE may promote disease progression and lead to poor prognosis.However,the differentiation and comorbidity of HUV and SLE are often neglected.Therefore,this paper reviews the potential association between HUV and SLE in epidemiology,clinical manifestations,histopathology,serology(complement and autoantibody,etc.),heredity and variation,in order to improve the understanding of the correlation between HUV and SLE,and provide reference for diagnosis,differentiation and early prevention.