miRNAs在白癜风治疗靶点中的研究进展

Research Progress of miRNAs in the Therapeutic Target of Vitiligo

白癜风(vitiligo)是一种常见的后天性色素脱失性皮肤黏膜疾病,发病机制尚不清楚,可能与免疫、感染、氧化应激等因素相关。白癜风目前容易诊断,难以治愈。miRNAs是转录后调节基因表达的小型非编码RNA分子,是各种细胞过程(如细胞生长、分化、凋亡和免疫反应)的基本调节器。多项研究发现,miRNAs及其靶基因在白癜风发生发展中起着重要作用,并提出这些miRNAs可通过调控自身免疫、内质网应激、氧化应激及细胞因子来影响疾病进展,可作为白癜风治疗的靶标。本文就近年来miRNAs及其靶基因在白癜风中的研究进展进行综述,以期为白癜风的靶向治疗提供新的思路。

Vitiligo is a common acquired skin and mucosa disease with depigmentation.The pathogenesis of VIT is unknown and may be related to immunity,infection and oxidative stress.Vitiligo is currently easy to diagnose and difficult to treat.miRNAs are small,non-coding RNA molecules that regulate gene expression after transcription and are fundamental regulators of various cellular processes,such as cell growth,differentiation,apoptosis and immune responses.Many studies have found that miRNAs and their target genes play an important role in the development of vitiligo,suggesting these miRNAs may influence disease focuses on the research progress of miRNAs and their target genes in vitiligo progression by regulating autoimmunity,endoplasmic reticulum stress,oxidative stress and cytokines.It can be used as a target in the treatment of vitiligo.This review aims to provide new ideas for the targeted therapy of vitiligo.