Kosakonia菌感染导致颌面部肉芽肿病1例首报

First Report of Orofacial Granulomatosis Caused by Kosakonia:A Case Report

患者女,32岁,左侧颌面部弥漫性肿胀伴进行性加重2年。皮肤科情况:左颊、颏部皮肤充血、肿胀、增厚,伴瘢痕组织,左下唇内侧可触及多处结节样突起。皮损组织病理示:上皮过度不全角化,固有层纤维结缔组织增生,少量嗜碱性变,部分小血管周围较多炎细胞浸润。诊断为颌面部肉芽肿。通过16S区域扩增子测序分析方法(16S rDNA Amplicon Sequencing)证实该病的主要致病菌是一种植物源性细菌Kosakonia。本例是首次报道由Kosakonia菌所致的颌面部肉芽肿病。

A 32-year-old female presented with ongoing diffuse sclerotic swelling on the left side of the maxillofacial region for two years.During the physical examination, a diffuse erythematous sclerotic area on the left cheek and chin was observed.Multiple nodules could be found on the inner side of the left lower lip.The biopsy of the lesion showed hyperparakeratosis of the epithelium.The connective tissue was fibrous with a small amount of basophilic change.Inflammatory cells infiltrated in some perivascular spaces.The diagnosis of orofacial granulomatosis was made.The 16 S region amplicon sequencing analysis further confirmed that Kosakonia,a plant-derived bacterium, was the main pathogen causing the condition.This is the first report of orofacial granulomatosis caused by Kosakonia.