新疆地区类天疱疮患者合并甲状腺功能异常的临床特征分析

Clinical Characteristics of Pemphigoid Patients with Thyroid Dysfunction in Xinjiang

目的通过分析新疆地区类天疱疮患者合并甲状腺功能异常的临床特征,探讨类天疱疮与甲状腺功能异常之间的相关性。方法收集2010年10月-2020年10月在本科初次住院治疗的137例类天疱疮患者及同期在本院体检中心体检的健康人群137例作为研究对象。两组在性别、年龄之间差异无统计学意义(P>0.05),具有可比性。收集两组所有研究对象的一般资料和甲状腺功能水平相关指标等数据,并对相关因素进行统计分析。结果(1)单因素分析:观察组及对照组患者在民族比例上有所差异,观察组患者的维吾尔族人数比例较对照组低,差异有统计学意义(P<0.05)。两组人群在年龄、性别方面相比,差异无统计学意义。(2)对病情严重程度不同的类天疱疮患者的甲功各项目采用方差分析进行比较,结果提示轻中重三组患者血清抗甲状腺球蛋白抗体水平差异具有统计学意义(P<0.05),提示不同病情严重程度患者的抗甲状腺球蛋白抗体(TGAb)水平有所不同。(3)观察组患者和对照组患者在甲功中血清游离三碘甲状腺原氨酸(FT3)和抗甲状腺过氧化物酶抗体(TPO)差异有统计学意义(P<0.05)。结论与健康对照组患者相比,类天疱疮患者对自身免疫性甲状腺炎有更高的发病风险。

Objective To explore the correlation between pemphigoid and thyroid dysfunction by analyzing the clinical features of pemphigoid patients with thyroid dysfunction in Xinjiang.Methods From October 2010 to October 2020,137 patients with pemphigus and 137 healthy people were selected as the research objects.There was no significant difference in gender and age between the two groups(P>0.05).It is comparable.The general information and thyroid level related indicators of the two groups were collected,and the related factors were analyzed.Results①Univariate analysis:the proportion of Uygur nationality in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in age and gender between the two groups.②Analysis of variance was used to compare the items of thyroid function in patients with different severity of pemphigoid.The results showed that there was significant difference in serum anti TG level among the three groups(P<0.05),suggesting that the level of anti thyroglobulin antibody in patients with different severity of pemphigoid was different.③There were significant differences in serum free triiodothyronine(FT3)and anti thyroid peroxidase antibody(TPO)between the observation group and the control group(P<0.05).Conclusion Patients with pemphigoid have a higher risk of autoimmune thyroiditis than healthy controls.