炎症因子及信号通路在瘢痕疙瘩中的研究进展

Advances in Research of Inflammatory Factors and Signal Pathways in Keloid

瘢痕疙瘩是皮肤创伤后修复过程的异常产物。目前瘢痕疙瘩发病机制尚存争议,许多研究表明炎症反应在瘢痕疙瘩形成过程中发挥着关键作用。组织细胞分泌的炎症因子参与介导瘢痕疙瘩中的炎症反应,其中IL-6、TGF-β、TNF-α等作为主要的炎症因子受到研究人员的广泛关注,而且取得一定的研究进展。炎症因子激活或者抑制相应的信号通路(JAK/STAT信号通路、NF-κB信号通路和MAPK信号通路),从而调节细胞增殖、分化和凋亡以及诱导炎症反应。对各种炎症因子及相关信号通路的研究将为瘢痕疙瘩的诊断和治疗提供新的思路。

Keloid is an abnormal product of the repair process after skin trauma.So far,the pathogenesis of keloid is still controversial.Many studies have shown that inflammation plays a key role in the formation of keloid.Especially,inflammatory cytokines secreted by tissue cells are involved in mediating the inflammatory response in keloid.Remarkably,the main inflammatory factors such as IL-6,TGF-β,and TNF-α,have been widely studied and some progress has been made.Inflammatory cytokines activate or inhibit the corresponding signal pathways(JAK/STAT signal pathway,NF-κB signal pathway and MAPK signal pathway),thus regulating cell proliferation,differentiation and apoptosis and inducing inflammatory response.The study of various inflammatory factors and related signal pathways will provide new ideas for the diagnosis and treatment of keloid.