T-SPOT.TB在活动性肺结核中的应用及敏感性分析

Application and Sensitivity Analysis of T-SPOT.TB in Active Tuberculosis

目的:分析结核感染T细胞斑点试验(T-SPOT.TB)对活动性肺结核(ATB)的诊断效能。方法:选取2019年2月至2021年2月广州市胸科医院收治的200例疑似ATB患者,所有患者均接受T-SPOT.TB及结核菌素皮肤试验(TST),以患者的最终临床诊断结果作为标准,计算并比较T-SPOT.TB与TST诊断ATB的诊断效能。结果:200例患者的最终临床诊断结果显示,存在ATB患者84例,且均为肺内结核。T-SPOT.TB诊断ATB的准确度、灵敏度高于TST,差异具有统计学意义(P<0.05),两种诊断方式诊断ATB的特异度比较,差异无统计学意义(P>0.05)。结论:T-SPOT.TB诊断ATB的诊断效能较TST更高,可将T-SPOT.TB结果作为ATB筛查的有效参考指标。

Objective To analyze the diagnostic efficacy of T cell spot test for tuberculosis infection(T-SPOT.TB)test in active tuberculosis(ATB).Methods A total of 200 suspected ATB patients admitted to Guangzhou Chest Hospital from February 2019 to February 2021 were selected.All patients received T-SPOT.TB and tuberculin skin test(TST),and the diagnostic efficacy of T-SPOT.TB and TST in diagnosing ATB was calculated and compared based on the final clinical diagnosis of the patients.Results The final clinical diagnosis of 200 patients showed the presence of ATB in 84 patients,all of whom had intrapulmonary tuberculosis.The accuracy and sensitivity of T-SPOT.TB in the diagnosis of ATB were significantly higher than those of the TST(P<0.05),but there was no significant difference in the specificity of the two diagnostic methods(P>0.05).Conclusion The diagnostic efficiency of T-SPOT.TB is higher than that of the TST,and the results of T-SPOT.TB can be used as an effective reference index for ATB screening.