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卵巢癌患者术前血小板增多与临床病理特征及预后的关系 被引量:2

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摘要 目的探讨卵巢癌患者术前血小板增多与临床病理特征及预后的关系。方法选取2017年1月至10月本院收治的卵巢癌患者85例为卵巢癌组,交界性肿瘤患者30例为卵巢交界性肿瘤组,良性病变患者10^(9)例为卵巢良性肿瘤组。术前检测各组血小板水平,将血小板计数≥300×10^(9)/L定义为血小板增多;收集卵巢癌患者的临床病理特征,术后进行为期3年的随访,记录生存时间。结果术前血小板计数在各组间比较差异均有统计学意义(均P<0.01);卵巢癌组患者术前血小板计数水平明显高于卵巢交界性肿瘤组、卵巢良性肿瘤组,差异均有统计学意义(均P<0.05);卵巢癌组中术前血小板计数≥300×10^(9)/L的患者比例明显高于卵巢交界性肿瘤组、卵巢良性肿瘤组,差异均有统计学意义(均P<0.05)。血小板计数≥300×10^(9)/L的卵巢癌患者盆腔积液深度明显高于血小板计数<300×10^(9)/L的患者,差异均有统计学意义(均P<0.01);血小板计数≥300×10^(9)/L的卵巢癌患者术后残余灶≥1 cm、手术病理分期Ⅲ~Ⅳ的患者比例明显高于血小板计数<300×10^(9)/L的患者,累积腹膜、隔面、大网膜的患者比例明显高于血小板计数<300×10^(9)/L的患者,上述差异均有统计学意义(均P<0.01)。术前血小板计数≥300×10^(9)/L的卵巢癌患者术后生存时间(29.50±2.70)个月,明显短于术前血小板计数<300×10^(9)/L的卵巢癌患者术后生存时间(33.90±1.60)个月,差异有统计学意义(P<0.01)。ROC曲线分析显示,术前血小板计数≥317.05×10^(9)/L时,能够最大程度预测卵巢癌患者的术后生存时间,AUC为0.645,具有较高的预测价值。结论卵巢癌患者术前血小板计数明显高于卵巢良性和交界性病变患者,术前血小板增多与卵巢癌患者临床病理特征密切相关,可作为患者预后水平的预测指标。
出处 《中国卫生工程学》 CAS 2022年第2期323-325,共3页 Chinese Journal of Public Health Engineering
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