淮南市2家医院门诊患者幽门螺杆菌感染状况及耐药性分析

Analysis of helicobacter pylori infection status and drug resistance among outpatients in two hospitals in Huainan city

目的分析淮南市2家医院门诊患者幽门螺杆菌(H.pylori)的感染率及耐药性,为临床合理用药提供有价值的参考依据。方法选取安徽理工大学第一附属医院和淮南东方医院集团总院2020年10月1日至2021年5月31日胃镜检查采集的胃黏膜组织进行分离培养和药敏试验。结果共采集门诊患者102例胃组织活检标本,分离培养出H.pylori 65例,检出率63.7%;药敏试验结果显示幽门螺杆菌对阿莫西林、阿莫西林/克拉维酸钾、头孢克肟、庆大霉素、四环素、盐酸多西环素、阿奇霉素、克拉霉素、左氧氟沙星、司帕沙星、甲硝唑、替硝唑、利福平和呋喃唑酮耐药率分别为27.69%、13.85%、49.23%、9.23%、16.92%、12.31%、40.00%、44.61%、23.08%、38.46%、47.69%、41.54%、38.46%和7.69%。结论淮南市2所医院行胃镜检查的患者H.pylori感染率高,且对头孢克肟、阿奇霉素、克拉霉素、甲硝唑和替硝唑等药物有较高耐药率。

Objective To preliminarily explore the infection rate and drug resistance of helicobacter pylori(H.pylori)in outpatients in 2 hospitals in Huainan,so as to provide valuable reference for clinical rational drug use.Methods From October 1,2020 to May 31,2021,the clinical gastric mucosa tissues of two representative tertiary general hospitals in Huainan area(the First Affiliated Hospital of Anhui University of Science&Technology and Huainan Oriental Hospital Group General Hospital)were collected for isolation,culture and drug sensitivity test.Results A total of 102 gastric biopsy specimens were collected from outpatients in two hospitals.65 cases of H.pylori were isolated and cultured,and the detection rate was 63.7%,the drug sensitivity results showed that the drug resistance rates of helicobacter pylori to amoxicillin,amoxicillin/clavulanate potassium,cefixime,gentamicin,tetracycline,doxycycline hydrochloride,azithromycin,clarithromycin,levofloxacin,sparfloxacin,metronidazole,tenitrile file,rifampicin and furazolidone were 27.69%,13.85%,49.23%,9.23%,16.92%,12.31%,40.00%and 44.61%respectively 23.08%,38.46%,47.69%,41.54%,38.46%and 7.69%.Conclusions There is a high infection rate of H.pylori in patients with stomach discomfort in Huainan Tianjia′an area.H.pylori had higher drug resistance rate to cefixime,azithromycin,clarithromycin,metronidazole and tinidazole,followed by amoxicillin,levofloxacin and rifampicin.