腹膜透析腹膜纤维化防治研究进展

Progress on preventing peritoneal fibrosis in peritoneal dialysis

腹膜透析(peritoneal dialysis,PD)具有保护残肾功能等诸多优势,已成为肾脏替代治疗的主流方式之一。长期腹膜透析导致腹膜透析腹膜纤维化是患者退出PD主要原因,且目前防治方案相对有限。许多学者针对腹膜透析腹膜纤维化进行了不断的探索与研究,笔者对近期腹膜透析腹膜纤维化的研究新进展进行了综述,从抑制慢性炎症、抑制腹膜新生血管、抑制促纤维化因子分泌、暂停腹膜透析、基因治疗、干细胞治疗等方面总结了防治腹膜透析腹膜纤维化的新方法,旨在为腹膜透析腹膜纤维化防治相关研究提供参考。

Peritoneal dialysis(PD)is one of the main methods of renal replacement therapy because of its advantages in protecting residual renal function.Peritoneal fibrosis caused by long⁃term peritoneal dialysis is the main reason for PD withdrawal.The strategy of prevention of peritoneal fibrosis is still limited.Many scholars have carried out continuous exploration and research on peritoneal dialysis.We reviewed the recent progress of peritoneal fibrosis in peritoneal dialysis.This paper summarizes the new methods for preventing and treating peritoneal fibrosis in peritoneal dialysis,including inhibiting chronic inflammation,inhibiting peritoneal neovascularization,inhibit⁃ing the secretion of fibrogenic factors,improving the biocompatibility of peritoneal dialysate,suspending peritoneal dialysis and gene therapy.The purpose is to provide reference for the prevention of peritoneal fibrosis on peritoneal dialysis.