正交试验法优选抗早颗粒提取及成型工艺

Optimization of Extraction and Forming Processes of Kangzao Granules by the Orthogonal Test

目的优选抗早颗粒的提取及成型工艺。方法以盐酸小檗碱含量和干膏得率的综合评分为评价指标,考察提取时间、提取次数、加水量,采用L_(9)(3^(4))正交试验法优选水提工艺;以颗粒得率和水分为评价指标,考察雾化压力、喷雾速率、物料温度,采用L_(9)(3^(4))正交试验优选流化床制粒工艺。结果提取次数对水提工艺影响显著,最佳水提工艺为加8倍量水,提取2次,每次40 min。雾化压力和喷雾速率对流化床制粒工艺的颗粒得率影响显著,最佳成型工艺为喷雾速率20 r/min,雾化压力0.14 MPa,物料温度55℃。结论该优选工艺稳定性好,可用于抗早颗粒的工业化生产。

Objective To optimize the extraction and forming processes of Kangzao Granules.Methods The water extraction process was investigated by the L_(9)(3^(4)) orthogonal test with the composite score of the content of berberine hydrochloride and yield of dry extract as the evaluation index,and with the extraction time,extraction times and amount of water addition as the investigation factors.The fluidized bed granulation process was optimized by the L_(9)(3^(4)) orthogonal test with the yield of granules and moisture as the evaluation indexes,and with the atomization pressure,spray speed and material temperature as the investigation factors.Results The extraction times had a significant effect on the water extraction process.The optimal water extraction process was as follows:adding eight times the amount of water,extracting two times,40 min each time.The atomization pressure and spray speed had a significant effect on the yield of granules by the fluidized bed granulation process.The optimal forming process was as follows:the spray speed was 20 r/min,the atomization pressure was 0.14 MPa and the material temperature was 55℃.Conclusion The optimal processes are stable,which can be used for the industrial production of Kangzao Granules.