Combination of anti-PD-L1 antibody with peptide MEL-dKLA targeting M2 tumor-associated macrophages suppresses breast cancer metastasis

Dear editors,Breast cancer is a leading cause of cancer-related deaths worldwide and is the most common cancer among women[1].The cause of death in patients with breast cancer is not the primary tumor itself but mainly metastasis.The most common sites of breast cancer metastasis include the bones,lungs,brain,lymph nodes,and liver.Importantly,lung metastasis has been a particular concern as it results in high patient morbidity and mortality rates[2].