卡前列甲酯栓联合卡前列素氨丁三醇对前置胎盘术后出血量和血流动力学的影响

The Effect of Carboprost Methylate Suppositories Combined with Carboprost Tromethamine Injection on Blood Volume and Hemodynamic After Placenta Previa Surgery

目的:探讨在前置胎盘术中应用卡前列甲酯栓联合卡前列素氨丁三醇对出血量和血流动力学的影响。方法:纳入宜春市妇幼保健院于2018年1月至2020年12月收治的68例行剖宫产手术的前置胎盘产妇作为研究对象,采用随机数字表法分为对照组和研究组。对照组采用卡前列素氨丁三醇进行治疗,研究组在对照组的基础上,增加卡前列甲酯栓的使用。对比两组患者的术后2 h和24 h的出血量,及治疗前后的血流动力学指标。结果:研究组患者在术后2 h、24 h的出血量明显低于对照组,组间比较均差异有统计学意义(P<0.05)。治疗前,两组患者的血流动力学指标(收缩压、舒张压、心率)差异无统计学意义(P>0.05)。经过治疗后,两组患者的血流动力学得到了有效的缓解,且研究组的改善情况明显优于对照组,差异有统计学意义(P<0.05)。研究组的总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论:在前置胎盘产妇的剖宫产手术中使用卡前列甲酯栓和卡前列素氨丁三醇联合治疗,相较于单独使用卡前列素氨丁三醇,更能有效地降低出血量和改善血流动力学指标,且不良反应发生率较低。

Objective:To investigate the effect of carboprost methylate suppositories combined with carboprost tromethamine injection on reducing bleeding volume and hemodynamics after placenta previa operation.Methods:68 pregnant women with placenta previa who underwent cesarean section in Yichun Maternal and Child Health Hospital from January 2018 to December 2020 were collected as the research object.They were randomly divided into control group and study group by digital table method.The control group was treated with carboprost tromethamine injection,and the study group increased the use of carboprost methylate suppositories on the basis of the control group.The amount of bleeding at 2 h and 24 h after operation and the hemodynamic indexes before and after treatment were compared between the two groups.Results:The amount of bleeding in the study group at 2 h and 24 h after operation was significantly lower than that in the control group(P<0.05).There was no significant difference in hemodynamic indexes(systolic blood pressure,diastolic blood pressure and heart rate)between the two groups before treatment(P>0.05).After treatment,the hemodynamic indexes of the two groups were effectively alleviated,and the improvement of the study group was significantly better than that of the control group,with statistical difference(P<0.05).The total effective rate of the study group was significantly higher than that of the control group with statistical difference(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group with statistical difference(P<0.05).Conclusion:Compared with carboprost tromethamine injection alone,the combined treatment of carboprost methylate suppositories and xinmupei in cesarean section of women with placenta previa can effectively reduce the amount of bleeding and the incidence of adverse reactions,and improve hemodynamic indexes.