双糖链蛋白聚糖在常见消化道恶性肿瘤中的表达及其与预后的关系

Expression of Bilycan in Common Malignant Tumor of Digestive Tract and Its Effects on Prognosis

目的研究双糖链蛋白聚糖(biglycan,BGN)在消化道恶性肿瘤中的表达情况,探讨其表达差异与临床病理特征以及预后生存的关系。方法挖掘肿瘤芯片数据库(Oncomine)、癌症基因组图谱(The Cancer Genome Atlas,TCGA)和基因表达谱交互分析数据库(Gene Expression Profiling Interactive Analysis,GEPIA),分析BGN在消化道恶性肿瘤中的表达,并对表达量与临床病理特征以及预后生存关系进行探讨。结果正常组织中共421项有关BGN在消化道肿瘤与正常组织间表达差异的研究结果具有统计学意义,其在消化道恶性肿瘤组织中表达量较正常组织更高[食管癌(中位秩=140.0,P=4.76×10^(-5))、胃癌(中位秩=140.0,P=4.76×10^(-5))、结直肠癌(中位秩=863.5,P=5.87×10^(-7))]。其表达量与食管癌、胃癌、直肠癌肿瘤浸润深度、结直肠癌淋巴转移情况及直肠癌肿瘤分期有相关性。BGN表达量与消化道恶性肿瘤患者总生存率有关。结论BGN在消化道恶性肿瘤中普遍呈现高表达,这种高表达与消化道恶性肿瘤浸润深度更深,结直肠癌淋巴结存在转移及直肠癌分期更晚相关,并且高表达患者总体生存率更低。

Objective To study the expression of biglycan(BGN)in malignant tumor of digestive tract and to explore the relationship between BGN expression and clinicopathological features as well as its prognosis.Methods The Oncomine,the Cancer Genome Atlas(TCGA)and Gene Expression Profiling Interactive Analysis(GEPIA)were excavated to analyze the expression of BGN in malignant tumor of digestive tract,and the relationship between the expression level and clinicopathological characteristics and the effects of prognosis were discussed.Results A total of 421 studies on BGN expression differences between gastrointestinal tumors and normal tissues showed statistically significant results.Its expression in malignant tumor of digestive tract was higher than that in normal tissue[esophageal cancer(median rank=140.0,P=4.76×10^(-5)),the gastric cancer(median rank=140.0,P=4.76×10^(-5)),colorectal cancer(median rank=863.5,P=5.87×10^(-7))].The expression level was correlated with invasive extent(esophageal,gastric and rectal cancer),lymph node metastasis(colorectal cancer)and neoplasm stage(rectal cancer).The expression level of BGN was related to the overall survival rate of patients with malignant tumor of digestive tract.Conclusion The expression of BGN is high in malignant tumor of digestive tract.The higher expression was correlated with deeper invasion(esophageal,gastric and rectal cancer),lymph node metastasis(colorectal cancer)and more advanced neoplasm stage(rectal cancer).The higher expression of BGN is associated with lower overall survival rate.