临床药师干预对血液淋巴瘤患者替加环素临床使用的影响

Effect of Clinical Pharmacist Intervention on Clinical Use of Tigecycline in Patients with Hematologic Lymphoma

目的:分析临床药师干预对医院血液淋巴瘤患者替加环素临床使用的影响。方法:选取2020年7月—2020年12月南方医科大学附属东莞医院血液淋巴瘤科收治但无临床药师干预的采用替加环素治疗患者(n=88)作为干预前组,选取2021年1月—2021年6月医院收治且有临床药师干预的采用替加环素治疗患者(n=33)作为干预后组,比较干预前后患者替加环素临床使用情况。结果:在临床药师干预后,临床上替加环素适应证和给药方案的合理率较前明显提高(分别为87.88%vs 69.09%和81.82%vs 41.82%),用药前微生物送检率也显著高于干预前(84.85%vs 21.82%)。结论:临床药师利用自身专业特长,干预、指导临床抗菌药物的使用,可以规范临床医生的用药行为,提高其合理用药水平。

Objective:To analyze the impact of clinical pharmacist intervention on clinical use of tigecycline in patients with hematologic lymphoma in the hospital.Methods:Patients admitted to Department of Hematology and Lymphoma of the Affiliated Dongguan Hospital of Southern Medical University from July 2020 to December 2020 and treated with tigecycline(n=88)without clinical pharmacist intervention were selected as the pre-intervention group,and patients admitted to the hospital from January 2021 to June 2021 and treated with tigecycline(n=33)with clinical pharmacist intervention were selected as the post-intervention group,to compare the clinical use of tigecycline in patients before and after the intervention.Results:After clinical pharmacist intervention,the clinical justification rate for tigecycline indications and dosing regimens was significantly higher than before(87.88%vs 69.09%and 81.82%vs 41.82%,respectively),and the pre-dosing microbiology specimen submission rate was also significantly increased(84.85%vs 21.82%).Conclusion:With professional expertise,clinical pharmacists intervened and guided the use of clinical antibacterial drugs,which could regulate medication behaviors of clinicians and improve their level of rational drug use.