“起立-行走”计时测试表现与中国华东地区老年人认知障碍相关

Timed Up and Go test is associated with cognitive impairment in elders from East China

目的本研究旨在探索“起立-行走”计时(TUG)测试表现与老年人认知功能的相关性。方法研究对象为江苏省如皋市长寿与老化研究队列。完成TUG测试,记录测试时间、步态稳定性和综合评分。采用中文版长谷川痴呆量表(HDS-R)评估认知功能。结果共1655名受试者(年龄75~84岁)完成TUG测试并进行认知评估纳入本研究。其中认知障碍组872例(52.7%),非认知障碍组783例(47.3%),TUG测试时间、步态稳定性和综合评分分别与HDS-R评分及其子成分呈负相关(P<0.001)。Logistic回归分析显示,TUG测试时间较长(OR=2.50,95%CI:1.76~3.55,P<0.001)、步态不稳(OR=1.11,95%CI:1.08~1.14,P<0.001)和综合评分差(OR=1.62,95%CI:1.39-1.89,P<0.001)与认知障碍风险增加独立相关。结论TUG测试中运动功能表现较差与认知功能障碍显著相关,TUG测试应用于社区的认知障碍早期风险筛查具有一定的可行性。

Objective To explore a potential relationship of Timed Up and Go(TUG)test to cognitive functions among elders.Methods The participants were from Rugao Longevity and Ageing Study conducted in Jiangsu province,China.TUG test was completed,recording gaits stability,test time and the overall scale.Cognitive function was evaluated using Chinese version of revised Hasegawa’s Dementia Scale(HDS-R).Results A total of 1655 participants(aged 75-84 years old)completed the TUG test and cognitive evaluation were included in this study.Among them,872(52.7%)in cognitive impairment group and 783(47.3%)in non-cognitive impairment group,the gait stability,time and scale of TUG test were inverse associated with HDS-R and its subcomponents,respectively(P<0.001).Logistic regression analysis showed that unsteady gait(OR=1.11,95%CI:1.08-1.14,P<0.001),longer time(OR=2.50,95%CI:1.76-3.55,P<0.001)and deteriorated scale(OR=1.62,95%CI:1.39-1.89,P<0.001)in TUG test were independently associated with increased risk of cognitive impairment.Conclusions Worse motor function performance on TUG test is significantly associated with cognitive impairment.The application of TUG test is potential method in early risk screening of cognitive impairment in community and has certain feasibility.