慢性肾脏病血管钙化机制的研究进展

Research progress on vascular calcification mechanism for chronic kidney disease

心血管事件是慢性肾脏病(CKD)及终末期肾病(ESRD)患者主要的死亡原因。研究认为血管钙化是导致心血管事件的独立危险因素。应除了传统心血管事件的预防,在CKD患者中,关注血管钙化发生机制、平衡促钙化因素与抑钙化因素,是慢性肾脏病矿物质-骨代谢异常(CKD-MBD)防治首要关注的问题。

Cardiovascular events are the main cause of death in chronic kidney disease(CKD)and end stage renal disease(ESRD).Studies have shown that vascular calcification is an independent risk factor for cardiovascular events.In addition to the prevention of cardiovascular events,paying attention to the mechanism of vascular calcification,keeping balance of pro-calcification factors and anti-calcification factors should be the primary concerns in prevention and treatment of chronic kidney disease with CKD-mineral and bone disorder(CKD-MBD)in CKD patients.