染色体4q25基因座上相关SNP与心房颤动易感性的Meta分析

Association between two SNPs at Chromosome 4q25 Locus and Atrial Fibrillation:Ameta-analysis

目的探讨染色体4q25基因座rs17042171、rs2200733多态性与房颤易感性间的关系。方法检索文献数据库查找相关的病例对照研究,提取相关数据,利用RevMan5.3软件相关研究进行Meta分析,采用Begg′s和Egger′s检验发表偏倚。结果共15篇文献被纳入,累计房颤病例5465例。Meta分析结果显示:SNP rs2200733与房颤发生密切相关[T VS C:OR=1.67,95%CI(1.39~2.01),P<0.00001;TT VS CC:OR=2.29,95%CI(1.11~4.72),P=0.02;TT+TC VS CC:OR=1.95,95%CI(1.54~2.46),P<0.00001;TT VS TC+CC:OR=2.03,95%CI(1.54~2.68),P<0.00001]。而SNP Rs17042171可能与房颤的发生相关,且A等位基因可能是房颤发生的风险因素。结论4q25基因座上SNP rs2200733与房颤发生风险相关,且携带T等位基因使房颤发生风险增加,而rs17042171多态性可能与房颤的发生有关,但需要更多的研究来证实。

Objective To investigate the relationship between SNP rs17042171 and SNP rs2200733 at chromosome 4q25 locus and atrial fibrillation(AF).Methods Search the literature database to find the relevant case-control studies.Extract the relevant data,and use revman 5.3 software for meta-analysis.Use the Begg′s and Egger′s tests to analyse the publishing bias.Results Fifteen articles including 5465 cases of AF were included in the meta-analysis.The meta-analysis showed that SNP rs2200733 was closely related to the occurrence of AF[T VS C:OR=1.67,95%CI(1.39-2.01),P<0.00001;TT VS CC:OR=2.29,95%CI(1.11-4.72),P=0.02;TT+TC VS CC:OR=1.95,95%CI(1.54-2.46),P<0.00001;TT VS TC+CC:OR=2.03,95%CI(1.54-2.68),P<0.00001].SNP rs17042171 polymorphism may be related to the occurrence of AF,and A allele may be a risk factor.Conclusion SNP rs2200733 at 4q25 locus was associated with the risk of AF,and T allele increases the risk of AF.Rs17042171 polymorphism may be related to the occurrence of AF,but more studies were needed to confirm it.