β淀粉样蛋白和tau蛋白磷酸化程度与颞叶癫痫患者认知缺陷相关性研究

Study on the Correlation between the Degree of Phosphorylation of Beta Amyloid and Tau Protein and Cognitive Deficits in Patients with Temporal Lobe Epilepsy

目的:探究β淀粉样蛋白(Aβ)和tau蛋白磷酸化程度与颞叶癫痫患者认知缺陷相关性。方法:2019年至2020年于我院接受治疗的70例颞叶癫痫患者作为本研究的实验组,同时纳入同期健康体检者70例作为本研究的对照组。对比两组一般临床指标、外周血清中β淀粉样蛋白和tau蛋白磷酸化程度;评估两组的智力、记忆力和认知功能障碍;通过Person法分析β淀粉样蛋白和tau蛋白磷酸化程度与颞叶癫痫患者认知缺陷相关性。结果:(1)比较显示实验组的Aβ1-28蛋白、Aβ1-40蛋白、tau蛋白和p-tau蛋白均高于对照组,但Aβ1-42蛋白低于对照组(P<0.05);(2)实验组语言智商(VIQ)、操作智商(PIQ)以及总智商(FIQ)评分均低于对照组(P<0.05);(3)实验组评估低于对照组(P<0.05);(4)实验组的MoCA评分显著低于对照组(P<0.05);(5)Aβ1-28蛋白、Aβ1-40蛋白、Tau蛋白和p-tau蛋白与颞叶癫痫患者认知缺陷存在正相关关系;Aβ1-42蛋白与颞叶癫痫患者认知缺陷则存在负相关关系(P<0.05)。结论:颞叶癫痫患者认知缺陷与tau蛋白磷酸化程度、Aβ1-28蛋白、Aβ1-42蛋白和Aβ1-40蛋白水平具有相关性,可作为认知缺陷的判断指标,为体检或临床发现颞叶癫痫患者是否存在认知功能缺陷提供依据。

Objective: To explore the correlation between the degree of phosphorylation of amyloid beta and Tau protein and cognitive deficits in patients with temporal lobe epilepsy. Methods: Seventy patients with temporal lobe epilepsy who received treatment in our hospital from 2019 to 2020 were included as the experimental group, and 70 healthy subjects were included as the control group.General clinical indicators and levels of amyloid beta and Tau protein phosphorylation in peripheral blood were compared between the two groups. Intelligence, memory and cognitive dysfunction were assessed in both groups. The Person method was used to analyze the correlation between the levels of phosphorylation of amyloid beta and Tau protein and cognitive deficits in temporal lobe epilepsy patients. Results:(1) The results showed that Aβ1-28 protein, Aβ1-40 protein, tau protein and p-tau protein in experimental group were higher than those in control group, but Aβ1-42 protein was lower than that in control group(P<0.05).(2) The VIQ, PIQ and FIQ scores of experimental group were lower than those of control group(P<0.05).(3) The experimental group was assessed lower than the control group(P<0.05).(4) The MoCA score of experimental group was lower than that of control group(P<0.05).(5) Aβ1-28 protein, Aβ1-40 protein, Tau protein and p-tau protein were positively correlated with cognitive deficits in temporal lobe epilepsy patients(P<0.05). There was a negative correlation between Aβ1-42 protein and cognitive impairment in temporal lobe epilepsy patients(P<0.05). Conclusion:Cognitive deficits in patients with temporal lobe epilepsy are correlated with the degree of tau protein phosphorylation, Aβ1-28 protein,Aβ1-42 protein and Aβ1-40 protein levels, which can be used as A judgment indicator of cognitive deficits and provide A basis for physical examination or clinical discovery of cognitive deficits in patients with temporal lobe epilepsy.