系统性红斑狼疮患者血清IL-2Rα、OAS1、DNase1L3与疾病活动度和早期肾损伤的关系研究

The Relationship Study between IL-2Rα,OAS1,DNase1L3 and Disease Activity and Early Renal Injury in Patients with Systemic Lupus Erythematosus

目的:探讨系统性红斑狼疮(SLE)患者血清白细胞介素-2受体α(IL-2Rα)、5’-寡腺苷酸合成酶1(OAS1)、脱氧核糖核酸酶1Like3(DNase1L3)与疾病活动度和早期肾损伤的关系。方法:纳入我院2018年1月-2021年12月期间收治的113例SLE患者,根据SLE疾病活动度评分(SLEDAI)将患者分为轻度组(n=48,SLEDAI评分0~9分)、中度组(n=28,SLEDAI评分10~14分)、重度组(n=37,SLEDAI评分≥15分)。根据患者肾小球滤过率(eGFR)将患者分为肾功能正常组[n=48,eGFR>90 m L/(min·1.73 m_(2))]和早期肾功能损伤组[n=65,eGFR为60~90 m L/(min·1.73 m_(2))]。对比轻度组、中度组和重度组的血清IL-2Rα、OAS1、DNase1L3水平。采用单因素及多因素Logistic回归分析SLE患者早期肾损伤的影响因素。结果:重度组、中度组的IL-2Rα、OAS1高于轻度组,且重度组高于中度组(P<0.05)。重度组、中度组的DNase1L3低于轻度组,且重度组低于中度组(P<0.05)。单因素分析结果显示,SLE患者早期肾损伤与年龄、SLEDAI评分、病程、三酰甘油(TG)、血小板(PLT)、血红蛋白(Hb)、血白蛋白(ALB)、超敏C反应蛋白(hs-CRP)、血尿素氮(BUN)、血肌酐(Scr)、C3、eGFR、血尿酸(UA)、β2微球蛋白(β2MG)、IL-2Rα、OAS1、DNase1L3有关(P<0.05)。多因素Logistic回归分析结果显示年龄、Scr、UA、β2MG、IL-2Rα、OAS1均是SLE患者早期肾损伤的影响因素(P<0.05)。结论:IL-2Rα、OAS1、DNase1L3参与着SLE的疾病进展,其中IL-2Rα、OAS1可与年龄、Scr、UA、β2MG等因素共同辅助评估早期肾功能损伤。

Objective:To investigate the relationship between serum interleukin-2 receptorα(IL-2Rα),5’-oligosenyl synthetase 1(OAS1),deoxyribonucinase 1Like3 (DNase1L3) and disease activity and early renal injury in patients with systemic lupus erythematosus(SLE).Methods:113 patients with SLE who were treated in our hospital from January 2018 to December 2021 were included.According to the SLE disease activity score (SLEDAI),the patients were divided into mild group (n=48,SLEDAI score 0~9 scores),moderate group (n=28,SLEDAI score 10~14 scores) and severe group (n=37,SLEDAI score≥15 scores).According to the glomerular filtration rate (eGFR),the patients were divided into normal renal function group[n=48,eGFR>90 m L/(min·1.73 m_(2))]and early renal function injury group[n=65,eGFR 60~90 m L/(min·1.73 m_(2))].The levels of IL-2Rα,OAS1 and DNase1L3 in mild group,moderate group and severe group were compared.Multivariate Logistic regression was used to analyze the influencing factors of early renal injury in patients with SLE.Results:The levels of IL-2Rαand OAS1 in severe group and moderate group were higher than those in mild group,and those in severe group were higher than those in moderate group(P<0.05).DNase1L3 in severe group and moderate group was lower than that in mild group,and that in severe group was lower than that in moderate group (P<0.05).Univariate analysis showed the early renal injury was related to age,SLEDAI score,course of disease,triglyceride (TG),platelet (PLT),hemoglobin (Hb),serum albumin (ALB),hypersensitive C-reactive protein (hs-CRP),blood urea nitrogen (BUN),serum creatinine (Scr),C3,eGFR,blood uric acid (UA),β2microglobulin (β2MG),IL-2Rα,OAS1,DNase1L3 in patients with SLE(P<0.05).Multivariate Logistic regression analysis showed that age,Scr,UA,β2MG,IL-2Rαand OAS1 were all influential factors of early renal injury in patients with SLE (P<0.05).Conclusion:IL-2Rα,OAS1 and DNase1L3 are involved in the disease progression of SLE,including IL-2Rα,OAS1 can be correlated with age,Scr,UA,β2MG and other factors assist in predicting early renal function injury.