核心稳定性训练联合高压氧对脑梗死恢复期患者血液流变学、脑能量代谢和血清NGF、NSE、MBP的影响

Effects of Core Stability Training Combined with Hyperbaric Oxygen on Hemorheology, Brain Energy Metabolism and Serum NGF,NSE and MBP in Convalescent Patients with Cerebral Infarction

目的:观察核心稳定性训练联合高压氧对脑梗死恢复期患者血液流变学、脑能量代谢和血清神经生长因子(NGF)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)的影响。方法:选择我院2018年3月~2021年3月期间收治的脑梗死恢复期患者103例。采用随机数字表法将患者分为对照组和观察组两组,例数分别为51例和52例。对照组患者接受核心稳定性训练,观察组患者接受核心稳定性训练联合高压氧治疗,对比两组疗效、血液流变学、脑能量代谢指标和血清NGF、NSE、MBP水平及相关量表评分。结果:观察组的临床总有效率高于对照组(P<0.05)。治疗后,两组上肢/下肢Lovett肌力评分升高,美国国立卫生研究院卒中量表(NIHSS)评分下降,且观察组的改变程度大于对照组(P<0.05)。治疗后,两组全血高切黏度、血细胞比容、全血低切黏度、血浆黏度下降,且观察组的改变程度大于对照组(P<0.05)。治疗后,两组血氧饱和度升高,空腹血糖、乳酸水平下降,且观察组的改变程度大于对照组(P<0.05)。治疗后,两组NGF水平升高,NSE、MBP水平下降,且观察组的改变程度大于对照组(P<0.05)。结论:核心稳定性训练联合高压氧应用于脑梗死恢复期患者,可促进其血液流变学、脑能量代谢改善,有效调节血清NGF、NSE、MBP水平,疗效明确。

Objective: To observe the effects of core stability training combined with hyperbaric oxygen on hemorheology, brain energy metabolism, serum nerve growth factor(NGF), neuron specific enolase(NSE) and myelin basic protein(MBP) in convalescent patients with cerebral infarction. Methods: 103 convalescent patients with cerebral infarction who were treated in our hospital from March 2018 to March 2021 were selected. The patients were divided into control group and observation group by random number table method, with 51 cases and 52 cases respectively. The patients in the control group received core stability training, and the patients in the observation group received core stability training combined with hyperbaric oxygen. The curative effect, hemorheology, brain energy metabolism indexes, serum NGF, NSE, MBP levels and related scales were compared between the two groups. Results: The total clinical effective rate in the observation group was higher than that in the control group(P<0.05). After treatment, Lovett muscle strength score of upper/lower limbs increased, and National Institutes of Health Stroke Scale(NIHSS) score decreased in the two groups, and the degree of change in the observation group was greater than that in the control group(P<0.05). After treatment, the whole blood high shear viscosity, hematocrit, whole blood low shear viscosity and plasma viscosity decreased in the two groups, and the degree of change in the observation group was greater than that in the control group(P<0.05). After treatment, blood oxygen saturation increased, and fasting blood glucose and lactate levels decreased in the two groups, and the degree of change in the observation group was greater than that in the control group(P<0.05). After treatment, NGF level increased, and NSE, MBP levels decreased in the two groups, and the degree of change in the observation group was greater than that in the control group(P<0.05). Conclusion: Core stability training combined with hy perbaric oxygen in conva lescent patients with cerebral infarction can promote the improvement of hemorheology and brain energy metabolism, and effectively regulate the levels of serum NGF, NSE and MBP, the curative effect is clear.