老年衰弱综合征与肌少症的病因机制及诊治进展

Etiological mechanism,diagnosis and treatment progress of senile asthenia syndrome and sarcopenia

衰弱是严重影响老年人健康和生活的、涉及多个系统的综合征。肌少症是与增龄相关的进行性骨骼肌量减少、力量减弱和躯体活动能力下降的综合征。两者成为老年失能领域的研究热点,越来越受到临床的关注。两者患病率随着年龄的增长而增加,临床表现相似,又各有其特点。该文对衰弱与肌少症病因机制,评估与诊断,治疗现状的进行综述,为开展两者之间机制关系研究及早期干预提供参考。

Asthenia is a syndrome involving multiple systems that seriously affects the health and life of the elderly.Sarcopenia is a syndrome associated with age-related progressive decrease in skeletal muscle mass,strength and physical activity.Both have become research hotspots in the field of senile disability and have attracted more and more attention.The prevalence of both increased with age,the clinical manifestations were similar,and each had its own characteristics.This paper systematically reviews the etiological mechanism,evaluation,diagnosis and treatment of asthenia and sarcopenia,so as to provide reference for the study of the mechanism relationship between them and early intervention.