预测颈动脉粥样硬化易损斑块的新型生物标志物研究进展

Research progress of novel biomarkers for predicting vulnerable plaque in carotidatherosclerosis

易损斑块是指动脉壁内稳定性差的斑块,其易破裂、脱落,导致原位血栓或多发微栓子形成。颈动脉粥样硬化易损斑块是缺血性脑卒中的主要致病机制,颈动脉斑块易损性增加脑缺血事件的发生。因此,早期鉴别易损斑块,对干预脑卒中高危因素、改善脑卒中预后具有重要意义。除各类影像技术外,循环生物标志物为识别颈动脉易损斑块提供了辅助手段。本综述回顾以往研究,讨论能够识别颈动脉易损斑块的新型生物标志物。

Vulnerable plaque refers to the plaque with poor stability in the arterial wall,which is easy to rupture and fall off,leading to the formation of in situ thrombus or multiple microemboli.Carotid atherosclerotic vulnerable plaque is the main pathogenic mechanism of ischemic stroke,and carotid plaque vulnerability increases the occurrence of cerebral ischemic events.Therefore,early identification of vulnerable plaques is of great significance for intervening high-risk factors for stroke and improving stroke prognosis.In addition to various imaging techniques,circulating biomarkers provide an adjunct to the identification of vulnerable carotid plaques.This article reviews previous studies,discussing novel biomarkers capable of identifying carotid vulnerable plaques.