抑亢丸联合甲巯咪唑治疗甲状腺功能亢进的有效性及安全性评价

Effectiveness and safety of Bolus for Inhibting hyperthythroidism(Yikang Pills) combined with methimazole in the treatment of hyperthyroidism

目的 探讨抑亢丸联合甲巯咪唑治疗甲状腺功能亢进的有效性及安全性。方法 回顾性分析2019年3月~2020年6月收治的甲状腺功能亢进患者124例,根据治疗方法不同将患者分为A(口服甲巯咪唑)、B(口服抑亢丸)、C(口服甲巯咪唑+抑亢丸)三组。记录三组患者治疗前后甲状腺功能、心率和血压及治疗后临床总有效率、不良反应发生率和随访3个月总复发率。结果 治疗后C组FT_(3)、FT_(4)、TT_(3)、TT_(4)明显低于A、B组,TSH高于A、B组,三组同组间治疗后FT_(3)、FT_(4)、TT_(3)、TT_(4)较治疗前降低,TSH较治疗后升高(P <0.05);治疗后C组心率、收缩压低于A组、B组,舒张压高于A组、B组,同组间比较治疗后心率、收缩压较治疗前降低,舒张压较治疗前升高(P <0.05);C组临床总有效率明显高于A组和B组(95.1%vs.75.6%,95.1%vs.78.6%,P <0.05);B组、C组总不良反应发生率低于A组(4.8%vs.24.4%,7.3%vs.24.4%,P <0.05);三组复发率差异无统计学意义(P> 0.05)。结论 抑亢丸联合甲巯咪唑治疗甲状腺功能亢进能有效改善患者甲状腺功能、心率及血压,且不良反应较少。

Objective To investigate the effectiveness and safety of Yikang Pills combined with methimazole in the treatment of hyperthyroidism.Methods A retrospective analysis was performed in 124 patients with hyperthyroidism admitted to our hospital from March 2019 to June 2020.According to different treatment methods,the patients were divided into groups A(oral methimazole),B(oral Yikang Pills),and C(oral methimazole + Yikang Pills).The thyroid function,heart rate and blood pressure of the three groups of patients were recorded before and after treatment,so were the total clinical effective rate after treatment,the incidence of adverse reactions and the total recurrence rate after 3 months of follow-up.Results After treatment,FT_(3),FT_(4),TT_(3),and TT_(4) in group C were significantly lower than those in groups A and B,and TSH was higher than that in groups A and B.FT_(3),FT_(4),TT_(3),and TT_(4) in the three groups after treatment in the same group were lower than before treatment,and TSH was lower than before and after treatment,the heart rate and systolic blood pressure of group C were lower than those of group A and B,and the diastolic blood pressure was higher than that of group A and B.The heart rate and systolic blood pressure after treatment were lower than those before treatment in the same group;the diastolic blood pressure was higher than before treatment(P < 0.05). The total clinical effective rate of group C was significantly higher than that of groups A and B(95.1% vs. 75.6%, 95.1% vs. 78.6%, P < 0.05).The total incidence of adverse reactions of group B and group C was lower than that of group A(4.8% vs. 24.4%, 7.3% vs. 24.4%, P < 0.05). There was no statistical difference in the recurrence rate between the three groups(P > 0.05). Conclusion Yikang Pills combined with methimazole in the treatment of hyperthyroidism can effectively improve patients’ thyroid function,heart rate and blood pressure,with fewer adverse reactions and significant clinical effects.