血栓通胶囊治疗脑梗死后遗症的疗效及对血液流变学和脑血流动力学指标的影响

The effect of Xueshuantong Capsule on the sequelae of cerebral infarction and its influence on hemorheology and cerebral hemodynamics

目的 探究与分析血栓通胶囊治疗脑梗死后遗症的疗效及对血液流变学、脑血流动力学指标的影响。方法 采取随机数字表法对2018年5月~2020年5月收治的脑梗死后遗症患者110例分组,各55例,对照组实施阿司匹林肠溶片与阿托伐他汀常规治疗,观察组在对照组基础上加用血栓通胶囊治疗,以治疗30 d为1个疗程,连续治疗2个疗程,对比两组疗效、美国国立卫生研究院卒中量表(NIHSS)评分、巴氏指数(BI)评分、血液流变学及脑血流动力学指标。结果 观察组与对照组相比临床总有效率较高,观察组治疗后与对照组治疗后相比NIHSS评分较低、BI评分较高,血液流变学指标中全血高切黏度、全血低切黏度、血浆黏度以及纤维蛋白原均较低,脑血流动力学指标基底动脉血流速、左侧椎动脉血流速、右侧椎动脉血流速及脑平均血流速较高,差异有统计学意义(P <0.05)。结论 血栓通胶囊联合常规方法治疗脑梗死后遗症可更好的改善患者神经及肢体功能,其主要作用机制可能与调节血液流变及脑血流相关。

Objective To explore and analyze the curative effect of Xueshuantong Capsule in treating sequelae of cerebral infarction and its influence on hemorheology and cerebral hemodynamics.Methods The random number table method was adopted to group the patients with sequelae of cerebral infarction from May 2018 to May 2020,55 cases in each group.The control group received conventional aspirin enteric-coated tablets and atorvastatin,and the observation group plus Xueshuantong Capsule treatment,with 30 days of treatment as a course of treatment,two consecutive courses of treatment,comparing the efficacy of the two groups,the national institutes of health stroke scale(NIHSS) score,barthel(BI) score,hemorheology and cerebral hemodynamics.Results Compared with the control group,the observation group had a higher total clinical effective rate.Compared with the control group after treatment,the observation group had lower NIHSS score and higher BI score.The shear viscosity,plasma viscosity and fibrinogen were all lower,and the cerebral hemodynamic indexes of basilar artery blood flow rate,left vertebral artery blood flow rate,right vertebral artery blood flow rate and average cerebral blood flow rate were higher.There was statistical significance(P < 0.05).Conclusion Xueshuantong Capsule assisting conventional methods to treat the sequelae of cerebral infarction can better improve the nerve and limb function of patients,and its main mechanism may be related to the regulation of blood rheology and cerebral blood flow.