BiPAP联合沙美特罗替卡松吸入气雾剂对慢性阻塞性肺疾病合并呼吸衰竭患者免疫球蛋白、肺功能及炎症因子的影响

Effects of BiPAP Combined with Salmeterol and Ficasone Inhalation Aerosol on Immune Globulin, Pulmonary Function and Inflammatory Factors in Patients with Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure

目的:探讨双相气道正压(BiPAP)联合沙美特罗替卡松吸入气雾剂对慢性阻塞性肺疾病合并呼吸衰竭患者免疫球蛋白(Ig)、肺功能及炎症因子的影响。方法:选取2018年6月至2021年6月该院慢性阻塞性肺疾病合并呼吸衰竭患者121例作为研究对象,按照随机数字表法分为观察组(BiPAP联合沙美特罗替卡松吸入气雾剂治疗,62例)与对照组(BiPAP治疗,59例)。对比两组患者治疗前和治疗后10 d的IgM、IgA、IgG、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))和最大呼气流量(MEF)等指标水平;观察治疗前,治疗后12、24、48和72 h的ROX指数。结果:重复测量方差分析结果显示,两组患者ROX指数的时点效应、组间效应、时点与组间的交互效应比较,差异有统计学意义(P<0.05)。治疗前,两组患者ROX指数、IgM、IgA、IgG、FVC、FEV_(1)、MEF、hs-CRP和IL-6水平比较,差异均无统计学意义(P>0.05)。治疗后12、24、48和72 h,观察组患者的ROX指数高于对照组,差异均有统计学意义(P<0.05)。治疗后10 d,观察组患者IgM、IgA、IgG、FVC、FEV_(1)和MEF水平高于对照组,hs-CRP、IL-6水平低于对照组,差异均有统计学意义(P<0.05)。结论:BiPAP联合沙美特罗替卡松吸入气雾剂用于慢性阻塞性肺疾病合并呼吸衰竭患者,疗效显著,有助于提高机体免疫功能和改善肺功能,降低炎症因子水平。

OBJECTIVE:To probe into the effects of bilevel positive airway pressure(BiPAP)combined with salmeterol and ficasone inhalation aerosol on immunoglobulin(Ig),pulmonary function and inflammatory factors in patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.METHODS:Totally 121 patients with COPD complicated with respiratory failure admitted into the hospital from Jun.2018 to Jun.2021 were extracted to be divided into the observation group(BiPAP combined with salmeterol and ficasone inhalation aerosol,n=62)and the control group(BiPAP,n=59)via the random number table.IgM,IgA,IgG,hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))and maximal expiratory flow(MEF)were compared between two groups before and after treatment of 10 d.ROX index before treatment and after treatment of 12,24,48 and 72 h was observed.RESULTS:Repeated measures analysis of variance showed that there were statistically significant differences in the time-point effect,inter-group effect and interaction effect of ROX index between two groups(P<0.05).Before treatment,there were no significant differences in ROX index,IgM,IgA,IgG,FVC,FEV_(1),MEF,hs-CRP and IL-6 between two groups(P>0.05).After treatment of 12,24,48 and 72 h,ROX index of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment of 10 d,IgM,IgA,IgG,FVC,FEV_(1) and MEF in the observation group were higher than those in the control group,while hs-CRP and IL-6 were lower than those in the control group,the differences were statistically significant(P<0.05).CONCLUSIONS:The efficacy of BiPAP combined with salmeterol and ficasone inhalation aerosol on immune globulin,pulmonary function and inflammatory factors in patients with COPD complicated with respiratory failure is significant,which can improve the immunity and lung function,and reduce the inflammatory factors.