Zoonotic attack: An underestimated threat of SARS-CoV-2?

As the first coronavirus pandemic iswalking into its third year,it is likely that the pandemic will transform to an endemic disease soon.With global efforts and measures on mass immunization,non-pharmaceutical interventions,and therapeutics advancements,the scales of death,illness,or social isolation have been relieved.However,endemic does not mean harmless;rather,it could be widespread and deadly.1 Ever since its emergence in 2019,SARS-CoV-2 has been mutating and evolving,leading to recent variant Omicron with significant transmissibility and immune-escaping capacities.