幽门螺杆菌根除后复发危险因素的meta分析

Meta-analysis on risk factors for the recurrence of Helicobacter pylori after eradication

目的探讨影响幽门螺杆菌(HP)根除后复发的危险因素。方法检索CNKI、万方、VIP、CBM、PubMed、Embase、The Cochrane Library和Web of Science数据库中关于HP根除后复发危险因素的病例对照研究。利用软件对数据进行分析。结果共纳入15篇文献。结果显示,萎缩性胃炎(OR=1.72,95%CI:1.04~2.83,P=0.030)、餐饮场所卫生条件(OR=0.19,95%CI:0.08~0.45,P=0.000)、根除后住院治疗(OR=6.18,95%CI:2.87~13.28,P=0.000)和根除后的侵入性诊断及治疗(OR=3.25,95%CI:1.95~5.43,P=0.000)与HP复发有关。结论本研究表明萎缩性胃炎、餐饮场所卫生条件差、根除后住院治疗和根除后侵入性诊断及治疗是HP复发的危险因素。

Objective To investigate the risk factors affecting the recurrence of Helicobacter pylori(HP)after eradication.Methods Case-control studies on risk factors for the recurrence of HP after eradication in CNKI,Wanfang,VIP,CBM,PubMed,Embase,The Cochrane Library and Web of Science databases were retrieved.The obtained data were analyzed using software.Results A total of 15 articles were included in this study.The results showed that atrophic gastritis(OR=1.72,95%CI:1.04~2.83,P=0.030),hygienic conditions in dining places(OR=0.19,95%CI:0.08~0.45,P=0.000),post-eradication hospitalized treatment(OR=6.18,95%CI:2.87~13.28,P=0.000)and post-eradication aggressive diagnosis and treatment(OR=3.25,95%CI:1.95~5.43,P=0.000)were factors associating with the recurrence of HP.Conclusion This study proves that atrophic gastritis,poor hygiene in dining places,post-eradication hospitalized treatment,and post-eradication aggressive diagnosis and treatment are risk factors for the recurrence of HP.