艾滋病合并播散型马尔尼菲蓝状菌病发热的临床特点分析

Analysis on clinical features of fever in AIDS complicated with disseminated Talaromyces marneffei

目的了解艾滋病合并播散型马尔尼菲篮状菌病发热的特点,为早期临床诊断提供理论依据。方法收集2012年1月至2018年12月艾滋病合并播散型马尔尼菲篮状菌病住院患者796例,将患者分为单纯组(播散型马尔尼菲篮状菌感染)和混合组(播散型马尔尼菲篮状菌病伴有其他发热疾病)。将病情特征纳入观察指标,分析比较两组发热特征及临床症状。结果符合观察条件的652例发热患者,单纯组168例、混合组484例。单纯组热程17(13,30)d,混合组热程18(15,31)d,差异有统计学意义(P<0.05)。伴随症状中,混合组出虚汗的比例较单纯组高(P<0.05)。结论艾滋病合并马尔尼菲篮状菌病体温特点表现为骤升高热,多为弛张热及不规则热,伴全身症状明显。混合感染热程偏长。

Objective To understand the features of fever in AIDS complicated with disseminated Talaromyces marneffei(DTM),so as to provide a theoretical basis for early clinical diagnosis.Methods A total of 796 patients with AIDS complicated with DTM who were hospitalized from January 2012 to December 2018 were selected as study subjects,and the patients were divided into the simple group(DTM infection)and the mixed group(DTM complicated with other febrile diseases).Incorporating disease characteristics into observation indicators,the features and clinical symptoms of fever in the two groups were analytically compared.Results Among the 652 patients with fever who met the observation conditions,168 patients were in the simple group and 484 patients in the mixed group.The duration of fever was 17(13,30)days in the simple group and 18(15,31)days in the mixed group,with a statistically significant difference(P<0.05).In terms of concomitant symptoms,the proportion of patients with cold sweat was higher in the mixed group than that in the simple group(P<0.05).Conclusion The body temperature of patients with AIDS complicated with DTM is characterized by a sudden increase in fever,mostly remittent and irregular fever,with significant systemic symptoms.And the duration of fever in mixed infections is rela tively longer.