miRNA-125与胰腺癌关系的研究进展

Research progress on the correlation between miRNA-125 and pancreatic cancer

miRNAs(microRNAs)是一种新型非编码RNA分子,能在转录后水平调节基因表达。miRNA参与调控不同的生物过程,在维持细胞稳态、细胞迁移、细胞增殖及凋亡与疾病的发生发展中发挥重要作用。越来越多的研究证明,胰腺癌中异常表达的miRNA-125通过抑制或者上调靶基因的表达,进而影响胰腺癌的发展、侵袭、迁移、增殖及凋亡,有望成为胰腺癌的生物标志物和治疗新靶点。本文就miRNA-125作为胰腺癌诊断标志物及治疗新靶点做一综述。

MiRNAs(microRNAs)are new non-coding RNA molecules,which can regulate gene expression at the post-transcriptional level.MiRNA is involved in regulating different biological processes,and plays an important role in maintaining cell homeostasis,cell migration,cell proliferation and apoptosis,and the occurrence and development of diseases.An increasing amount of research has proved that the abnormal expression of miRNA-125 in pancreatic cancer can impact the development,invasion,migration,proliferation and apoptosis of pancreatic cancer by inhibiting or up-regulating the expression of target genes,and it is expected to become a biological marker and a new therapeutic target for pancreatic cancer.In this paper,miRNA-125 is reviewed as a diagnostic marker and a new therapeu tic target for pancreatic cancer.