连续性肾脏替代治疗与间歇性血液透析治疗重症急性肾衰的临床研究

Clinical study of continuous renal replacement therapy and intermittent hemodialysis in the treatment of severe acute renal failure

目的 分析连续性肾脏替代治疗与间歇性血液透析治疗重症急性肾衰的效果。方法 80例重症急性肾衰患者,随机分为对照组与观察组,各40例。对照组给予间歇性血液透析治疗,观察组给予连续性肾脏替代治疗。比较两组血红蛋白、白蛋白水平,治疗前后患者血磷、甲状旁腺激素、尿素氮、血肌酐水平,治疗效果,并发症发生情况。结果 观察组血红蛋白水平(7.51±2.75)g/dl、白蛋白水平(36.24±5.21)g/L均高于对照组的(5.52±1.21)g/dl、(31.56±3.12)g/L,差异有统计学意义(P<0.05)。治疗后,观察组血磷、甲状旁腺激素、尿素氮、血肌酐水平均低于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率97.50%高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组并发症发生率7.50%低于对照组的25.00%,差异有统计学意义(P<0.05)。结论 连续性肾脏替代治疗对于重症急性肾衰的效果确切,优于采取间歇性血液透析的方式,可更好改善患者的临床症状,减少并发症,值得推广。

Objective To analyze the difference between continuous renal replacement therapy and intermittent hemodialysis in the treatment of severe acute renal failure.Methods A total of 80 patients with severe acute renal failure were randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with intermittent hemodialysis,and the observation group was treated with continuous renal replacement therapy.Both groups were compared in terms of hemoglobin,albumin,serum phosphorus,parathyroid hormone,blood urea nitrogen and serum creatinine before and after treatment,therapeutic effects,and complications.Results The hemoglobin(7.51±2.75)g/dl and albumin level(36.24±5.21)g/L in the observation group were higher than(5.52±1.21)g/dl and(31.56±3.12)g/L in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum phosphorus,parathyroid hormone,blood urea nitrogen and serum creatinine in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate 97.50%of the observation group was higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).The complication rate 7.50%in the observation group was lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Continuous renal replacement therapy has a definite effect on severe acute renal failure,and is better than intermittent hemodialysis.It can better improve the clinical symptoms of patients and reduce complications,and is worthy of promotion.