丙种球蛋白静脉滴注辅助治疗小儿糖尿病合并重症肺炎的效果

Effect of intravenous drip of gamma globulin on children with diabetes mellitus and severe pneumonia

目的 调查研究丙种球蛋白静脉滴注辅助治疗小儿糖尿病合并重症肺炎的效果。方法 80例小儿糖尿病合并重症肺炎患儿,随机分为对照组和观察组,各40例。对照组接受常规治疗,观察组在对照组基础上使用丙种球蛋白静脉滴注辅助治疗。对比两组治疗效果、不良反应发生率、症状消退时间、住院时间、治疗前后的血糖指标。结果 观察组治疗总有效率为97.5%,高于对照组的82.5%,差异有统计学意义(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。观察组咳嗽缓解时间为(3.01±1.27)d,肺部啰音消失时间为(3.62±0.83)d,退热时间为(2.36±0.73)d,住院时间为(8.32±1.91)d;对照组咳嗽缓解时间为(5.62±1.51)d,肺部啰音消失时间为(5.27±1.39)d,退热时间为(4.54±1.16)d,住院时间为(12.09±2.39)d。观察组咳嗽缓解时间、肺部啰音消失时间、退热时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,两组空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)均较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05)。结论 对小儿糖尿病合并重症肺炎患儿使用丙种球蛋白静脉滴注辅助治疗更具有可行性,治疗整体效果更好,患儿恢复更快而且不会增加患儿的身体负担。

Objective To investigate and study the effect of intravenous drip of gamma globulin on children with diabetes mellitus and severe pneumonia.Methods A total of 80 children with diabetes mellitus and severe pneumonia were randomly divided into control group and observation group,with 40 cases in each group.The control group received conventional treatment,and the observation group received adjuvant therapy with intravenous drip of gamma globulin on the basis of the control group.The therapeutic effect,incidence of adverse reactions,symptom remission time,hospitalization time,and blood glucose indexes before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 97.5%,which was higher than 82.5%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).In the observation group,the cough remission time was(3.01±1.27)d,the pulmonary rales disappearance time was(3.62±0.83)d,the duration of fever was(2.36±0.73)d,and the hospitalization time was(8.32±1.91)d;in the control group,the cough remission time was(5.62±1.51)d,the pulmonary rales disappearance time(5.27±1.39)d,the duration of fever was(4.54±1.16)d,and the hospitalization time was(12.09±2.39)d.The cough remission time,pulmonary rales disappearance time,duration of fever and hospitalization time in the observation group were all shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),and 2 h postprandial glucose(2 h PG)in the two groups were all decreased compared with those before treatment,and the observation group was lower than the control group.All the differences were statistically significant(P<0.05).Conclusion Intravenous drip of gamma globulin as adjunctive therapy for children with diabetes mellitus combined with severe pneumonia is more feasible,and the overall effect of treatment is better and the child recovers faster without increasing the physical burden of the child.