基于MR成像获得新辅助治疗后乳腺肿瘤退缩模式与病理反应的相关性

The correlation between breast tumor regression pattern and pathological response after neoadjuvant therapy based on MR imaging

目的 探讨新辅助治疗(NAT)后基于MR成像获得乳腺肿瘤退缩模式与病理反应的相关性.方法 收集2019年12月至2020年12月NAT后手术前59例局部进展期乳腺癌病灶MR图像退缩模式以及术后病理标本资料,分析两者间的相关性.结果 59例病灶中,向心性收缩38例(64.41%),其中病理缓解31例(81.58%),病理无缓解7例(18.42%);非向心性收缩21例(35.59%),其中病理缓解11例(52.38%),病理无缓解10例(47.62%).乳腺癌肿瘤退缩模式与NAT后病理反应差异有统计学意义(P<0.05).结论 乳腺癌肿瘤退缩模式与NAT后病理反应具有相关性,向心性收缩更多出现病理缓解,非向心性收缩多出现病理无缓解.

Objective To investigate the correlation between MR-based patterns of tumor regression and pathological response after neoadjuvant therapy(NAT).Methods The MR image regression patterns and postoperative pathological specimen data of 59 locally advanced breast cancer lesions before surgery were collected from December 2019 to December 2020,and analyze their correlation.Results There were 38 cases(64.41%)of concentric contraction after NAT in 59 cases,including 31 cases(81.58%)of pathological response and 7 cases of non-pathological response(18.42%).Besides,there were 21 cases(35.59%)of non-concentric contraction,which included 11 cases(52.38%)of pathological response and 10 cases of non-pathological response(47.62%).There was significant difference between the pattern of tumor regression after NAT and pathological response(P<0.05).Conclusion There is significant correlation between the pattern of tumor regression after NAT and pathological response.the tumors with concentric shrinkage on MRI present more pathological response and the tumors with non-concentric shrinkage present more non-pathological response.