健脾和胃方对睡眠剥夺孕妇特定肠道菌群及睡眠状况的影响

The effects of strengthening spleen-stomach decoction on specific intestinal flora and sleep status of sleep deprived pregnant women

目的 探讨健脾和胃方对睡眠剥夺孕妇特定肠道菌群及睡眠状况的影响.方法 将诊断为睡眠剥夺孕妇96例患者随机分为观察组与对照组,各48例.观察组采用健脾和胃中药汤剂治疗;对照组以双歧杆菌三联活菌口服治疗;两组均连续治疗4周.比较两组治疗前后肠道主要菌群结构、匹兹堡睡眠质量指数(PSQI)变化以及血清五羟色胺(5-HT)的含量.结果 观察组治疗后,肠道类杆菌、优杆菌、胃瘤菌含量均有上升,差异有统计学意义(P<0.05).与对照组比较,肠球菌和肠杆菌有所下降,差异有统计学意义(P<0.05).治疗后,观察组PSQI各项指标评分与总分均明显降低(P<0.05),对照组睡眠效率评分及总分降低(P<0.05);观察组入睡时间、睡眠效率、睡眠障碍、日间功能障碍评分及总分治疗前后差值高于对照组(P<0.05).观察组PSQI各项指标评分与总分治疗前后差值高于对照组(P<0.05).与治疗前比较,观察组治疗4周血清5-HT升高(P<0.05),且高于对照组(P<0.05).结论 健脾和胃中药应用能够调节睡眠剥夺孕妇的肠道菌群,治疗睡眠剥夺疗效优于双歧杆菌三联活菌组,其机制可能通过影响机体5-HT的含量起到治疗作用.

Objective To explore the effect of strengthening spleen-stomach decoction on specific intestinal flora and sleep status in sleep deprived pregnant women.Methods 96 pregnant women with sleep deprivation were randomly divided into observation group.Hid control group,with 48 cases in each group.The observation group was treated with strengthening spleen-stomach decoction,the control group was treated with bifidobacterium triple viable,both groups were treated for 4 weeks.The scores of Bacteroides,Bifidobacterium,Lactobacillus and Pittsburgh sleep quality index(PSQI)before and after treatment were compared between the two groups.Results The content of Bacteroides,Eubacterium,Gastroma increased significantly in the observation group,with statistical sigiiificance(P<0.05).However,Enterococcus and Enterobacteriaceae decreased significantly compared with the control group,with statistical significance(P<0.05).After treatment,the PSQI index scores and total scores were significantly lower than those in the control group(P<0.05),the differences of sleep time,sleep efficiency,sleep disorder,daytime dysfiniction score and total score befbre and after treatment in the observation group were significantly higher than those in the control group(P<0.05).The difference of PSQI index score and total score before and after treatment in the observation group was significantly higher than that in the control group(P<0.05).Compared with befbre treatment,the semni 5-HT in the observation group increased after 4 weeks of treatinent(P<0.05),and the serum 5-HT in the control group was lower than that in the observation group after 4 weeks of treatnient(P<0.05).Conclusion Strengthening spleen-stomach decoction can regulate the intestinal flora of sleep deprived pregnant women,and the therapeutic effect is better than that of Bifidobacterium triple viable group,its mechanisni may play a therapeutic role by affecting the content of 5-HT.