褪黑素与特发性肺纤维化关系的研究进展

Research progress on the relationship between melatonin and idiopathic pulmonary fibrosis

特发性肺纤维化(IPF)是一种慢性、进行性、纤维化性肺部疾病,病因不清,发病机制也未完全明确,目前尚无可以治愈的药物。褪黑素(MT)是脊椎动物松果体产生和释放的一种神经激素,多项研究表明MT具有抗纤维化作用,可以通过减轻氧化应激、抑制炎症反应、抑制上皮-间质转化、抗凋亡、调节自噬等多种途径抑制肺纤维化的发展。本文总结了近年来MT与IPF关系的研究成果,以期为IPF的临床治疗提供新的思路。

Idiopathic pulmonary fibrosis(IPF) is a chronic,progressive and fibrotic lung disease.The etiology is unclear and the pathogenesis is not completely clear.At present,there is no curable drug.Melatonin(MT) is a neurohormone produced and released by the pineal gland of vertebrates.Many studies have shown that melatonin has anti fibrosis effect,which can inhibit the development of pulmonary fibrosis by reducing oxidative stress,inhibiting inflammatory response,inhibiting epithelial mesenchymal transformation,anti apoptosis and regulating autophagy.This paper summarizes the research results of the relationship between MT and IPF in recent years,in order to provide new ideas for the clinical treatment of IPF.