脊髓灰质炎病毒受体与胃癌患者预后的关系

Relationship between poliovirus receptor and prognosis of gastric cancer patients

目的探讨脊髓灰质炎病毒受体(PVR)对胃癌患者预后的价值。方法采用生物信息学方法分析PVR mRNA在胃癌组织及癌旁正常组织中的表达及其与预后的关系。回顾性分析73例接受手术治疗的胃癌患者的临床病理资料。采用免疫组化方法检测胃癌组织及癌旁正常组织中PVR的表达水平,分析其与胃癌患者临床病理特征的关系。结果胃癌组织中PVR mRNA的表达水平高于癌旁正常组织(P<0.05)。PVR的表达与胃癌患者的临床预后有关,PVR的表达越高,胃癌患者的总生存率(P=0.011)和无病生存率(P=0.032)越低。免疫组化染色结果显示,PVR在胃癌组织中高表达,主要表达于细胞质,而在正常胃组织中不表达或低表达。PVR的高表达与肿瘤大小(P=0.001)和术后3年复发(P=0.013)相关。结论 PVR在胃癌组织中过度表达,PVR高表达的胃癌患者预后较差。PVR水平对胃癌患者的预后评估具有重要价值。

Objective To explore the prognostic value of poliovirus receptor(PVR)in patients with gastric cancer.Methods Bioinformatics methods were used to analyze the expression of PVR mRNA in gastric cancer tissues and adjacent normal tissues and its relationship with prognosis.The clinicopathological data of 73 gastric cancer patients who underwent surgical treatment were retrospectively analyzed.Immunohistochemical method was used to detect the expression level of PVR in gastric cancer tissue and adjacent normal tissue,and its relationship with the clinicopathological characteristics of gastric cancer patients was analyzed.Results The expression level of PVR mRNA in gastric cancer tissues was higher than that in adjacent normal tissues(P<0.05).The expression of PVR is related to the clinical prognosis of gastric cancer patients,and the higher the expression of PVR,the lower the overall survival rate(P=0.011)and the disease-free survival rate(P=0.032)of gastric cancer patients.The results of immunohistochemical staining showed that PVR was highly expressed in gastric cancer tissue,mainly in the cytoplasm,while it was not expressed or lowly expressed in normal gastric tissue.High expression of PVR was associated with tumor size(P=0.001)and recurrence 3-years after surgery(P=0.013).Conclusions PVR is overexpressed in gastric cancer tissue,and gastric cancer patients with high expression of PVR have a worse prognosis.The level of PVR has great value for the prognosis evaluation of gastric cancer patients.