EGFR在病毒性传染病中的研究进展

Research Advance of EGFR in Viral Infections

表皮生长因子受体(EGFR)是受体酪氨酸激酶(RTKs)家族成员之一,广泛表达于多种细胞的细胞膜上。病毒入侵宿主细胞的过程在很大程度上依赖于病毒特异性结合的细胞表面受体,一旦病毒识别到这类表面受体,将激活附着、摄取、胞内运输以及渗透到细胞质溶胶等一系列胞内机制。已有研究表明,许多病毒可以利用EGFR促进自身的感染过程。因此,阐明病毒与EGFR之间复杂的相互作用对于全面了解病毒感染宿主细胞的机制是极其重要的。本文将重点从EGFR介导病毒入侵、病毒利用EGFR延长细胞存活时间、病毒调节EGFR逃避宿主免疫监控等方向做详细讲述,以便为病毒性传染病的防治提供新的见解。

Epidermal growth factor receptor(EGFR),a member of the receptor tyrosine kinases(RTKs)family,is widely expressed on the membranes of many cells.The process of virus invasion into the host cells depends to a large extent on its specific binding receptors on the cell surfaces.While the virus recognizes the surface receptors,it activates a number of intracellular mechanisms,including attachment,uptake,intracellular transport and infiltration into cytoplasmic aerosols.It has been shown that many viruses can use EGFR to promote the infection process.Therefore,elucidating the complex interactions between viruses and EGFR is extremely important for a comprehensive understanding of how these viruses invade host cells.This review will focus on EGFR-mediated virus invasion,the use of EGFR by viruses to prolong cell survival time,and the regulation of EGFR by viruses to evade host immune monitoring,which will provide new insights for the prevention and treatment of viral infectious diseases.