清咳平喘颗粒联合莫西沙星治疗成人轻中度社区获得性肺炎临床观察

Clinical observation of Qingke Pingchuan Granules combined with moxifloxacin in treatment of adult mild to moderate community acquired pneumonia

目的探究清咳平喘颗粒联合莫西沙星治疗成人轻中度社区获得性肺炎(community acquired pneumonia,CAP)的临床应用价值。方法回顾性分析空军特色医学中心2019年1月至2021年9月间收治的成人轻中度CAP患者100例临床资料,按治疗方案不同将其分为对照组50例和试验组50例,对照组患者静脉注射盐酸莫西沙星氯化钠注射液,0.4 g/次,1次/d,以及右美沙芬愈创甘油醚糖浆止咳治疗;试验组患者在对照组基础上口服清咳平喘颗粒,10 g/次,3次/d。两组均治疗7 d。比较两组患者用药后的疗效以及发热持续时间、咳嗽减轻时间、肺部啰音减少时间、住院总天数、炎性指标、不良反应发生的差异。结果试验组患者治疗后的总有效率为96%,明显高于对照组的88%(P<0.05);治疗后试验组患者发热持续时间、咳嗽减轻时间、肺部啰音减少时间、住院总天数均短于对照组(P<0.05、0.01);两组所有患者炎性指标水平与治疗前比较均显著降低(P<0.05),治疗后试验组细菌及混合感染患者炎性指标白细胞数、C-反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)水平均明显低于对照组(P<0.05)。结论清咳平喘颗粒具有抗炎、止咳、增强细胞免疫和体液免疫的作用,联合化学药治疗成人轻中度CAP症状改善较快,有一定疗效,值得推广应用。

Objective To explore the clinical application value of Qingke Pingchuan Granules(清咳平喘颗粒)combined with moxifloxacin in the treatment of adult mild to moderate community acquired pneumonia(CAP).Methods Clinical data of 100 adult patients with mild to moderate CAP admitted to Air Force Medical Center from January 2019 to September 2021 were retrospectively analyzed,and they were divided into control group(n=50)and experimental group(n=50)according to different treatment regimens.Control group received intravenous injection of moxifloxacin hydrochloride injection,0.4 g each time,once a day,and dextromethorphan guaifenesine syrup for cough relief.Experimental group was given Qingke Pingchuan Granule orally on the basis of control group,10 g each time,3 times/d.Both groups were treated for 7 d.The efficacy,fever duration,cough relief time,lung rales reduction time,total hospitalization days,inflammatory indicators and adverse reactions were compared between the two groups.Results The total effective rate of experimental group was 96%,which was significantly higher than that of control group(88%)(P<0.05).After treatment,the fever duration,cough relief time,lung rales reduction time and total hospitalization days in experimental group were shorter than those in control group(P<0.05,0.01).The levels of inflammatory indexes of all patients in two groups were significantly decreased compared with before treatment(P<0.05).After treatment,the number of white blood cells,C-reactive protein(CRP)and procalcitonin(PCT),inflammatory indexes of patients infected with bacteria and mixed infection in experimental group were significantly lower than those in control group(P<0.05).Conclusion Qingke Pingchuan Granule has effects of anti-inflammatory,cough suppressant,enhancing cellular immunity and humoral immunity.Combined with chemical drugs,the mild and moderate CAP symptoms in adults after treatment has improved quickly with a certain efficacy,which is worthy of popularization and application.