南蛇藤及其有效成分抗胃癌作用机制的研究进展

Research progress on anti-gastric cancer mechanism of Celastrus orbiculatus and its active compounds

随着中医药抗肿瘤研究的深入,越来越多的中药被发现并证实具有很好的抗肿瘤效果。其中南蛇藤及其有效成分抗肿瘤的研究已近20年,许多研究已经证实南蛇藤及其有效成分具有很好的抗胃癌活性。已经被分离和证实具有抗肿瘤活性的成分包括萜类化合物、脂肪类化合物和苷类化合物等,其中萜类化合物的抗肿瘤活性最强。南蛇藤及其有效成分抗胃癌的主要作用为抑制胃癌细胞的增殖、诱导胃癌细胞凋亡、抑制胃癌细胞侵袭转移和上皮间质转化(epithelial-mesenchymal transformation,EMT)、抑制胃癌血管生成和逆转胃癌多药耐药等。这些研究结果对深入挖掘南蛇藤抗胃癌活性成分和分子机制具有非常重要意义。从南蛇藤抗胃癌的有效成分及其南蛇藤抗胃癌的作用机制研究2个方面对南蛇藤抗胃癌的相关研究进行综述,为今后南蛇藤的进一步开发和利用提供参考。

With the deepening of antitumor research in traditional Chinese medicine, more and more Chinese materia medica have been discovered and proved to have good antitumor effects. The research on antitumor effect of Nansheteng(Celastrus orbiculatus Thunb.) and its active components has been has been carried out for nearly 20 years. Many studies have been confirmed that C.orbiculatus and its active components have anti-gastric cancer activity. Terpenoids, lipids and glycosides have been isolated and confirmed to have antitumor activity, among which terpenoids have the strongest antitumor activity. The main anti-gastric cancer effects of C. orbiculatus and its active components were inhibition of gastric cancer cell proliferation, induction of gastric cancer cell apoptosis,inhibition of invasion and metastasis of gastric cancer cells and epithelial-mesenchymal transformation(EMT), inhibition of gastric cancer angiogenesis and reversal of multidrug resistance, etc. These results are of great significance to further explore the anti-gastric cancer active components and molecular mechanism of C. orbiculatus. In this paper, the relevant researches on anti-gastric cancer were reviewed from two aspects: The active components for anti-gastric cancer and the mechanism for anti-gastric cancer, and provides reference for further development and utilization of C. orbiculatus in the future.