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补髓益智汤联合辛伐他汀治疗老年痴呆症疗效及对脑脊液中Aβ1-42水平影响 被引量:1

The effect of Busui Yizhi Decoction combined with Simvastatin in the treatment of Alzheimer's disease and the effect on the level of Aβ1-42 in cerebrospinal fluid
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摘要 目的探讨补髓益智汤联合辛伐他汀治疗老年痴呆症疗效及对脑脊液中Aβ1-42水平影响。方法选取本院2019年5月至2021年8月收治的80例老年痴呆症患者作为研究对象,随机将其分为观察组(n=40)和对照组(n=40)。观察组采用补髓益智汤联合辛伐他汀对老年痴呆症患者进行治疗,对照组采用辛伐他汀联合常规治疗方式对老年痴呆症患者进行治疗,对比两组患者神经递质水平、脑脊液Aβ1-42水平、血脂水平、认知功能(MMSE)评分、日常生活能力(ADL)量表评分以及不良反应发生率。结果治疗前两组血清5-HT、Ach、脑脊液Aβ1-42水平对比差异无统计学意义(P>0.05),治疗后两组患者血清5-HT、Ach、脑脊液Aβ1-42水平均升高,并且观察组高于对照组(P<0.05);两组患者治疗前血清总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平对比差异无统计学意义(P>0.05),治疗后两组患者的TC、TG、LDL-C水平均下降,并且观察组低于对照组(P<0.05),治疗后两组患者的HDL-C水平均升高,并且观察组高于对照组(P<0.05);治疗前两组患者的MMSE评分以及ADL评分对比差异无统计学意义(P>0.05),治疗后两组MMSE评分以及ADL评分均升高,且观察组较对照组高(P<0.05);治疗前两组不良反应发生率对比差异无统计学意义(P>0.05),治疗后两组均降低,且观察组较对照组低(P<0.05)。结论将补髓益智汤联合辛伐他汀应用于老年痴呆症患者当中,可以提高患者神经递质水平,提升脑脊液Aβ1-42水平,改善血脂水平,并且提高认知功能以及生活能力,降低不良反应,本研究值得临床借鉴。 Objective To explore the effect of Busui Yizhi Decoction combined with simvastatin in the treatment of Alzheimer's disease and the effect on Aβ1-42 in cerebrospinal fluid Horizontal influence.Methods A total of 80 patients with Alzheimer's disease treated in our hospital from May 2019 to August 2021 were randomly divided into observation group(n=40)and control group(n=40).The observation group was treated with Bushui Yizhi Decoction Combined with simvastatin,and the control group was treated with simvastatin combined with conventional treatment.Neurotransmitter levels,cerebrospinal fluid Aβ1-42 levels,blood lipid levels,cognitive function(MMSE)score,daily living ability(ADL)scale score and the incidence of adverse reactions were compared between 2 groups.Results Before treatment,there was no difference in serum 5-HT,Ach and CSF Aβ1-42 levels between 2 groups(P>0.05),but after treatment,the levels of serum 5-HT,Ach and CSF Aβ1-42 in 2 groups were increased,and the observation group was higher than the control group(P<0.05);There was no significant difference in the levels of serum total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)between the two groups before treatment(P>0.05).After treatment,the levels of TC,TG and LDL-C in the two groups decreased,and the levels in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of HDL-C in the two groups increased,And the observation group was higher than the control group(P<0.05);There was no significant difference in MMSE score and ADL score between the two groups before treatment(P>0.05).After treatment,MMSE score and ADL score increased in the two groups,and the observation group was higher than the control group(P<0.05);There was no difference in the incidence of adverse reactions between the two groups before treatment(P>0.05).After treatment,the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion The application of Bumedui Yizi Decoction combined with simvastatin in patients with Alzheimer's disease can improve the level of neurotransmitters,cerebrospinal fluid Aβ1-42 level,improve blood lipid level,improve cognitive function and living ability,and reduce adverse reactions.This study is worthy of clinical reference.
作者 敖祖松 AO Zusong(Department of Neurology,Henan Xinhe Hospital,Xinyang,Henan,465200)
出处 《实验与检验医学》 CAS 2022年第2期166-170,共5页 Experimental and Laboratory Medicine
关键词 补髓益智汤 辛伐他汀 老年痴呆症 脑脊液 Aβ1-42水平 Busui Yizhi Decoction Simvastatin Alzheimer's disease Cerebrospinal fluid Aβ1-42 level
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